作用机制 NLRP3 抑制剂 产品介绍 Information MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. Targets NLRP3 (BMDM-based assay); NLRP3 (HMDM-based assay) 7.5 nM; 8.1 nM In vitro MCC950 is a potent, selectiv...
Saline or MCC950 (3 mg/kg), an inhibitor of NLRP3, was injected at 1 and 3 h after reperfusion. Cognition was assessed over time and neuronal density, blood-brain barrier (BBB) permeability as well as NW remodeling (aquaporin-4 [AQP4] polarity) was measured on day 14 after stroke. ...
发货地上海 更新日期2024-12-23 QQ交谈微信洽谈 产品详情 中文名称:MCC950(CP-456773)CAS:210826-40-7 纯度规格:98%产品类别:活性分子 MCC950 is a potent, selectiveNLRP3inhibitor withIC50of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. IC50 & Target: IC50: 7.5 nM (NLRP3, in BMDMs),...
MCC950是一种有效的选择性NLRP3抑制剂,作用于BMDMs和HMDMs,IC50分别为7.5nM和8.1nM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:210826-40-7别名:CP-456773纯度:96.37%分子式:C20H24N2O5S分子量:404.48结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关搜索:NLRP...
产品活性:MCC950 (CP-456773; CRID3) 是一种有效,选择性的 NLRP3 抑制剂,在 BMDMs 和 HMDMs中的 IC50 分别为 7.5 nM 和 8.1 nM。 体外:MCC950 在纳摩尔浓度下阻断典型和非典型 NLRP3 激活。MCC950 特异性抑制 NLRP3 激活,但不抑制 AIM2、NLRC4 或 NLRP1 激活。在小鼠骨髓来源的巨噬细胞 (BMDM) ...
[1].Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55. [2].Gan W, et al. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 infl...
简介：MCC950 sodium是一种有效，选择性的 NLRP3 抑制剂，在BMDMs 和 HMDMs中的 IC50 分别为 7.5 nM 和 8.1 nM。MCC950 sodium物理化学性质：MCC950 sodium详细介绍：MCC950 sodium参考文献：[1]. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of ...
生化机理MCC950(CP-456773,CRID3)是一种强效的 NLRP3(NOD 样受体(NLR)家族,含 pyrin 结构域蛋白 3)选择性抑制剂,在 BMDMs 和 HMDMs 中的 IC50 分别为 7.5 nM 和 8.1 nM。 储存温度-80℃储存 运输条件超低温冰袋运输 产品介绍 Information MCC950 MCC950 is a potent and selective inhibitor of NLRP3 ...
[1]. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55. 品牌介绍: • MCE (MedChemExpress) 拥有200 多种*仅有化合物库,我们致力于为*科研客户提供前沿的高品质小分子活性化合物; ...
MCC950 sodium价格:￥664/支产品详情:MCC950 sodium is a potent, selective?NLRP3?inhibitor with?IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. Chem... 纯度:98% 包装规格:5 mg 用途:科学研究、研发 货号:C101322 品牌:ChemeGen ...