However, the mechanism of action of MCC950 remains unknown. Here, we characterize the mechanism of action of MCC950 in both wild-type and autoinflammatory-related NLRP3 mutants, and demonstrate that MCC950 closes the 'open' conformation of active NLRP3....
实验结果(Results):Treatment of mice with MCC950 delayed the onset and reduced the severity of EAE. 文献2,Chawla S et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives.. Br J Dermatol. 2008 Dec;159(6):1267-74. PMID:18811684 ...
Sustained activation of the SIRT3-NLRP3 inflammasome has been associated with worse outcomes after ischemic stroke. The objective of this study was to examine the potential mechanism by which the SIRT3-NLRP3 inflammasome affects neural stem and progenitor cells (NSPCs) after transient middle cerebral...
Therefore, the purpose of our study was to elucidate the therapeutic effects of MCC950 on line M83 mice with symptoms of cognitive impairment and the related mechanism of action of NLRP3 inhibition on α-synuclein. Access through your organization Check access to the full text by signing in thr...
Mcc950 is a potent and specific inhibitor of the NLRP3 inflammasome but its influence on DR has not been studied. Thus, we evaluated the anti-inflammatory effects of Mcc950 on high-glucose-induced human retinal endothelial cells (HRECs) and the potential underlying mechanism. In surgical excise...
However, the exact mechanism of its action is still ambiguous. Accumulating investigations imply that chloride efflux–dependent ASC speck oligomerization and potassium efflux–dependent activation of caspase-1 are the two relatively independent, but indispensable events for NLRP3 inflammasome activation. ...
mechanism. In surgical excised proliferative membranes from DR patients, high expression of NLRP3, caspase 1 and IL-1βwas observed and co-localization of NLRP3 and IL-1βoccurred in CD31+ labeled HRECs. Moreover, in high-glucose-stimulated HRECs, increased production of the NLRP3 ...
This review summarized the structure and mechanism of action of MCC950 in the control of NLRP3-dependent inflammation and the role of MCC950 in the treatment of NLRP3-mediated inflammatory diseases based on the latest studies.doi:10.1016/j.intimp.2022.108595Saba Bakhshi...