significant differences in the pharmacokinetics of midazolam (a CYP3A4 substrate) or on the formation of its active metabolite (1-hydroxymidazolam) were observed when a single 7.5- mg dose of midazolam was administered prior to and after a 14-day regimen of VYNDAQEL 20-mg once daily. ...
Usual Pediatric Dose for Acne 15 years or older: 1 tablet orally once a day Comments: Not all preparations are indicated for the treatment of acne; the manufacturer product information should be consulted. Use should be reserved for the treatment of acne only if the patient desires an oral co...
Maximum dose: 1600 mg per dayComments:Doses higher than 1600 mg per day have not been studied in mania associated with bipolar disorder.Use: For the treatment of acute manic or mixed episodes associated with bipolar disorder.Usual Pediatric Dose for EpilepsyLess...
Newborns (0 to 3 months) at Risk for Cardiac Failure: Consider a lower initial dose; increase dose every 4 to 6 weeks as needed based on clinical and laboratory response Pediatric Patients at Risk for Hyperactivity: Initial dose should be one-fourth the recommended full replacement dose; increa...