The majority of both mast cell types were electrically silent at rest with a resting membrane potential of around 0 mV. Following IgE-dependent activation, >90% of human peripheral blood-derived mast cells responded within 2 min with the development of a Ca~(2+)- activated K~+ current ...
MASTCELLACTIVATIONSYNDROMEDISORDER：肥大细胞活化..
“The response of mast cells to dengue virus can be beneficial or detrimental. When a mosquito injects dengue virus (brown hexagons) into the skin, the viruses are detected by specific antibodies (green) or unidentified receptors (blue) on the surface of resting (i.e., non-activated) mast...
H3K27ac ChIP-seq and Omni-ATAC-seq were prepared from resting (UN) and activated mast cells (ST). b The number of GATA2 and MITF binding motifs (left panel) and occupancy (total bound sites and reads per gene, middle panel) and normalized bound sites and reads per kb per enhancer (...
Mast cells (MC) are key effector cells of allergic diseases and resistance to helminthic parasites and induce or amplify diverse innate and adaptive immune responses. The signals controlling MC mobilization during inflammation are not fully understood. S
Mast cells, basophils and B cell connection network. It has been proven that both resting and activated mast cells (MCs) and basophils are able to induce a significant increase in proliferation and survival o... S Merluzzi,E Betto,AA Ceccaroni,... - 《Molecular Immunology》 被引量: 0发...
When transferred to Rag1-deficient mice, activated F5/L∆P T cells were more efficient at entering the PLNs than F5/WT T cells exposed to antigen, indicating that L-selectin shedding prevents the re-entry of activated T cells into the PLNs. These studies show that the physi- ological ...
Membrane phosphoinositide-activated signals in mast cells and basophils. and J.R. Cunha-Melo, 1988, Membrane phosphoinositide- activated signals in mast cells and basophils, Prog. Allergy 42, 123... MA Beaven,JR Cunha-Melo - 《Prog Allergy》 被引量: 195发表: 1988年 Signal transduction in mas...
tissue, and co-localization of MCs with these cell types was revealed by spatial transcriptome analysis. In conclusion, this study finds decreased MC density in CRC compared to normal tissue, but highlights a shift in MC phenotype fromCMA1highresting cells to activatedTPSAB1high,CPA3high, and...
(nonactivated, i.e., resting mast cells), in which the histamine concentration was ∼10 ng/ml, perfusion of the hearts with 48/80 increased the level of histamine by more than 10-fold, indicating that activation of cardiac mast cells with ensuing release of histamine had occurred (Fig. ...