Thus HMC-1 human mast cells or primary bone marrow-derived human mast cells were cocultured with activated and with resting T cells, Mast cells cocultured with activated T cells released histamine and beta-hexo
Mast cells are fascinating, multifunctional, bone marrow-derived, tissue-dwelling cells. They can be activated to degranulate in minutes, not only by IgE and antigen signaling via the high-affinity receptor for IgE, but also by a diverse group of stimuli. These cells can release a wide variet...
In human cervical carcinoma, resting and activated mast cells in metastasis were associated with worse overall survival in patients [25]. In human thyroid cancer, mast cell percentage is associated with tumor size, stage, and distant metastasis [22]. High extramural mast cell counts are associated...
Mast cells were identified and counted in the perivascular tissue of the aortic root at the site of atherosclerosis. A mast cell was considered resting when all granula were maintained inside the cell, while mast cells were assessed as activated when granula were deposited in the tissue ...
Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune di
Mast cells were identified and counted in the perivascular tissue of the aortic root at the site of atherosclerosis. A mast cell was considered resting when all granula were maintained inside the cell, while mast cells were assessed as activated when granula were deposited in the tissue ...
Mast cells also play an important role in gastric cancer. Mast cells secrete tryptase through the activation of protease-activated receptor-2 (PAR2), mitogen-activated protein kinase (MAPK), and the c-kit receptor;The density of tryptase-positive mast cells has a substantial correlation with the...
In the high-risk group, the immune scores of T cell resting memory CD4 + T cell, activated memory CD4 + T cell, M1 macrophage infiltration were all significantly lower than those in the low-risk group (Fig. 5C, p < 0.05). Mast cells-related molecules in the classification...
After removal of the excess antibody, the cells were stimulated with 100 ng/mL human serum albumin (HSA) conjugated with DNP (DNP-HSA; Sigma-Aldrich) as an Ag for 10 min at 37 °C. As required for experiments, the cells were directly activated by 10 μg/mL Compound 48/80 (C48/80...
37,40,48 Therefore, it seems that mismatched environmental or lifestyle factor arrivals lower the threshold of IgE-dependent or -independent mast cell activation during the active phase and, as a result, mast cells easily become activated at any time of the day. Thus, the clock mechanism may...