Bacterial products at the site of infection are thought to induce the emigration and maturation of APCs, but the signals that control T-cell recruitment to the lymph nodes are unknown. Work now published in Nature Immunology shows a central role for mast cells in this process. Mast cells are...
Mast cell development The development of mast cells remain poorly understood, as they are unique among hematopoietic cells in that they mature in peripheral tissues, rather than in lymphoid organs or in circulation. Originally believed to be derived from ba...
WT and L∆P mice crossed with ani- mals expressing a T-cell receptor spe- cific for an influenza-virus-derived peptide (F5). When transferred to Rag1-deficient mice, activated F5/L∆P T cells were more efficient at entering the PLNs than F5/WT T cells exposed to antigen, ...
Your symptoms largely respond to medications that block or slow the release of the chemicals found in mast cells. Erica Sloan, SELF, 3 Dec. 2024 In this condition, the body makes too many mast cells, a type of immune cell that triggers inflammation. Sarah Hudgens, Health, 20 Dec. 2024 ...
The objective in this study was to investigate the effects of mast cells and specifically mast cell tryptase on fibroblast migration and the role of PAR2 activation.关键词: Human lung fibroblast, Lung, Mast cell, Migration, Protease activated receptor 2, Tryptase ...
Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. Mast cells, IgE, and TNF, which have been implicated in human atopic asthma, contribute significantly to the allergic airway inflammation induced by ovalbu... S Naka...
The mast cell and allergic diseases: role in pathogenesis and implications for therapy Mast cells have long been recognized for their role in the genesis of allergic inflammation; and more recently for their participation in innate and acquir... JM Brown,TM Wilson,DD Metcalfe - 《Clinical & Exp...
mast cells and cell-to-cell interactions in airways1-3 WM Gold,SC Lazarus 被引量: 0发表: 0年 Mast cell-T cell interactions In addition to being a major effector cell in the elicitation of allergic inflammation, mast cells have been found to be activated in various T cell–media... YA...
cells may also participate in the reparative process. A striking accumulation of mast cells in areas of collagen deposition andcellular proliferationis observed during the proliferative phase of healing(117); mast cell growth may be mediated through upregulation ofStem Cell Factor(SCF), a potent ...
摘要: Please cite this paper as: Mast cell lines HMC-1 and LAD2 in comparison with mature human skin mast cells – drastically reduced levels of tryptase and chymase in mast cell lines. Experimental Dermatology 2010; 19: 845–847.关键词:...