Mast cell tryptase in a case of ana- phylaxis due to repeat antibiotic exposure. Leg Med (Tokyo). 2009;11:234---6.Carson, H.J.; Cook, B.A. (2009) Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure. Legal medicine (Tokyo), Vol. 11, No. 5, (...
Mast Cell Overview What are mast cells? Mast cells are predominantly tissue-resident granulocytes that, along withbasophils, play a key role in allergy and anaphylaxis, as they are a predominant cellular source of histamine. Originally believed to be tissue-re...
Abbreviations: MCAS, mast cell activation syndromes; MMAS, monoclonal mast cell activation syndrome; sBT, serum baseline tryptase; SM, systemic mastocytosis. Data from Refs.19,20,30,31,37,38 Thus, anaphylaxis presently remains a clinical entity and its understanding for an allergist remains limited...
Mast cells promote the invasive behavior of pancreatic ductal adenocarcinoma by increasing levels of IL-13, tryptase, VEGF, platelet-derived growth factor, and fibroblast growth factor-2, all while maintaining cell membrane integrity [84, 85]. During pancreatitis, mast cells accumulate in the ...
which does not rely on mast cell activation, modulate IgE-mediated responses [14]. Upon ligand binding to the mast cell receptor, the mast cell may release mediators such as histamine and proteases (chymases and tryptases) through degranulation, in conjunction with the de novo synthesis of lipi...
The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J. Allergy Clin. Immunol. 2018, 142, 1173–1184. [Google Scholar] [CrossRef] [Green Version] Skarnes, W.C.; ...
Cloning of the cDNA and gene of mouse mast cell protease-6-transcription by progenitor mast cells and mast cells of the connective tissue subclass. J Biol Chem. 1991;266(6):3847–53. CAS PubMed Google Scholar Caughey GH. Protease mediators of anaphylaxis, chapter 6. In: Castells MC, ...
with systemic mastocytosis generally have tryptase levels of 20 ng/mL or greater. Clonal Mast Cells in Anaphylaxis Since the description of the first patient with mastocytosis, the gold standard for diagnosing this disorder has been the demonstration of increased mast cells in tissue biopsies ...
We demonstrate that mast cell expansion occurring in response to IL-4 signals confers increased sensitivity to IgE-mediated systemic anaphylaxis. Our findings establish that both the addition of exogenous IL-4 and a cell-intrinsic increase in sensitivity to the cytokine are sufficient to enhance the...
Increased mast cell tryptase in sudden infant death-anaphylaxis, hypoxia or artefact? Clin. Exp. Allergy (1999) E. Edston et al. Anaphylactoid shock—a common cause of death in heroin addicts? Allergy (1997) There are more references available in the full text version of this article. ...