Evaluation of mast cell activation (tryptase) in two patients suffering from druginduced hypotensoid reactions. Agents Actions 1991; 33(1–2): 218–20Matsson P, Enander I, Andersson AS, Nystrand J, Schwartz L, Watkins J (1991) Evaluation of mast cell activation (tryptase) in two patients...
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. Better methods are needed to assess mast-cell activation in vivo and to distinguish the activation of mast cells from that of basophils. Tryptase, a neutra... LB Schwartz,DD Metcalfe,JS Miller,.....
The PAR-2 AP SLIGRL-NH2 did not induce eosinophil activation by any of the methods we employed. Conclusion: Our data indicate that mast cell tryptase may affect eosinophil activation status independently of PAR-2. 展开 关键词: eosinophil, mast cell, inflammation, mast cell tryptase, lung, ...
Both basophils and mast cells release proteases upon degranulation, and while some of them, such as Granzyme B, are secreted by both cell types, many are unique to mast cells. Chymases, tryptases, cathepsin G, and matrix metalloproteases (MMPs) are ...
METHODS: (1) Mast cell activation (ie, tryptase release) and pro-inflammatory mediator release were determined in peritoneal lavage fluid obtained at consecutive time points during open, laparoscopic and transvaginal gynaecological surgery. (... FO The,RJ Bennink,WM Ankum,... - Gut 被引量: 187...
mast cell growth may be mediated through upregulation ofStem Cell Factor(SCF), a potent mast cell chemoattractant(117). Mast cells may be important in cardiac repair by producing and releasing a wide variety of angiogenic andfibrogenicmediators, including the fibrogenic mast cell proteasestryptaseand...
The importance of PAR2 activation by mast cells and mast cell tryptase for the migratory effects of fibroblasts was investigated by pre-treatment with the PAR2 antagonist P2pal-18S. The expression of PAR2 was analyzed on fibroblasts and mast cells. Results The migratory capacity of HFL-1 cells...
The objective in this study was to investigate the effects of mast cells and specifically mast cell tryptase on fibroblast migration and the role of PAR2 activation.关键词: Human lung fibroblast, Lung, Mast cell, Migration, Protease activated receptor 2, Tryptase ...
After activation mast cells release preformed mediators, e.g. histamine, heparin, tryptase, and produce prostaglandins, leucotriens, tromboxans and calicrein from the phospholipids of cell membranes. On addition many cytokines are released, e.g. IL-4, IL-5, IL-6, and TNF-α. It is thought...
Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory granules of all mammalian organisms. These enzymes are released along with other mediators into the extracellular medium upon mast cell activation/degranulation. Among the trypsin-like enzymes, tryptases are...