Human mast cell tryptase : a stimulus of microvascular leakage and mast cell activation [J]. Eur J Pharmacol, 1997, 328 (1): 89-97He S. Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation. Eur J Pharmacol. 1997;328:89-97....
Mechanism for activation of mouse mast cell tryptase: dependence on heparin and acidic pH for formation of active tetramers of mouse mast cell protease 6. Biochemistry 2000;39:13068-13077.Hallgren, J., Karlson, U., Poorafshar, M., Hellman, L., and Pejler, G. (2000) Mechanism for ...
Figure 2. Basophil and mast cell activators and inflammatory mediators. Both basophils and mast cells release proteases upon degranulation, and while some of them, such as Granzyme B, are secreted by both cell types, many are unique to mast cells. Chymases...
Many patients who call requesting an initialpsychiatricconsultation are suffering from a common condition known as mast cell activation syndrome (MCAS). MCAS can present with extremely diverse fluctuating symptoms.Brain fog,anxiety,depression, andinsomniaare among the most common symptoms. ...
Tryptase, a neutral endoprotease, is secreted by activated mast cells in human tissues. Tryptase levels in various body fluids have been used as an indicator of mast cell activation. The authors determined tryptase levels in unstimulated tears collected from the following groups of patients: (1) ...
Actually, increased levels of circulating tryptase have been found to associate with CVDs. Here we review the biological relevance of the circulating tryptase as a biomarker of mast cell activity in CVDs, with special emphasis on the relationship between activation of mast cells in their tissue ...
mast cell growth may be mediated through upregulation ofStem Cell Factor(SCF), a potent mast cell chemoattractant(117). Mast cells may be important in cardiac repair by producing and releasing a wide variety of angiogenic andfibrogenicmediators, including the fibrogenic mast cell proteasestryptaseand...
Both basophils and mast cells release proteases upon degranulation, and while some of them, such as Granzyme B, are secreted by both cell types, many are unique to mast cells. Chymases, tryptases, cathepsin G, and matrix metalloproteases (MMPs) are ...
Mast cells are activated by a number of stimuli, including antigen, superoxides, complement protein, neuropeptides and lipoproteins, resulting in activation and degranulation. Mast cell degranulation and thereby release of mast cell tryptase as well as histamine, leukotrienes and cytokines into the ...
Clone REAL798 recognizes human mast cell tryptase, an important marker of mast cell activation and inflammatory mediator. Tryptase is involved in angiogenesis after its release from activated MC granules. Tryptase+mast cell infiltration leads to an unfavorable clinical outcome in solid tumors. Mast Cel...