In the general population, higher body mass index (BMI) is associated with increased all-cause mortality [1], with the nadir of the curve generally found in the upper normal-weight range [2], though the relationship is J-shaped [3], as also underweight carries an increased risk of death...
Lymph Node FNA in Patient with Suspected Cholangiocarcinoma (Dr. Sahai) Main Duct IPMN (Dr. Paquin) Monitoring Pancreatic Pseudocyst (Dr. Sahai) Multiple Pancreatic Masses (Dr. Sahai) Neuroendocrine Tumor? (Dr. Sahai) Normal Pancreas 1
Broad-spectrum kinase profiling in live cells with lysine-targeted sulfonyl fluoride probes. J. Am. Chem. Soc. 139, 680–685 (2017). Article CAS PubMed PubMed Central Google Scholar Dalton, S. E. et al. Selectively targeting the kinome-conserved lysine of PI3Kδ as a general approach ...
Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Ramnik J. Xavier Contributions S.G. wrote the software and conducted experiments. G.H. adapted MAGMa substructure labelling for auxiliary model...
A growing body of evidence supports the comorbidity between depression (DEP) and obesity, yet the genetic mechanisms underlying this association remain unclear. Our study explored the shared genetic architecture and causal associations of DEP with BMI. W
Distinguishing between different phosphorylation sites within a peptide sequence, especially if the potential phosphorylation sites are in close proximity, remains challenging for SIMSI-Transfer. This is not an exclusive shortcoming of the presented method but rather a general issue in peptide identification...
Although assessment of WC, in addition to BMI, competes for the limited time available during patient appraisal within clinical practice [9], obtaining two measurements (one for general obesity, and one for central obesity) does not entail any extra cost [14]. In light of the increasing ...
4c), consistent with the observation in Fig. 4a. Although these two clusters had similar cell numbers from each region, one was more localized to the granular layer of the dentate gyrus and pyramidal layer, whereas the other was more general to cornu ammonis (CA) areas. Similarly, several ...
We sought to simplify the discovery of immunogenic mutant peptides by characterizing their general properties. We developed an approach that combines whole-exome and transcriptome sequencing analysis with mass spectrometry to identify neo-epitopes in two widely used murine tumour models. Of the >1,...
1. A method for determining lifetime healthcare expenditures for an individual, on-demand and in real-time, based on body mass index on a computing system having a data harvester, a data aggregator, aggregate health profiles, a two-part regression model, and a final part regression model, ...