测序结果共鉴定出17个差异表达的已知miRNAs,以及15个新的miRNAs,对差异表达miRNAs的靶基因进行KEGG Pathway富集分析,发现某些差异表达miRNAs可能通过靶向甘油磷脂代谢,脂肪酸代谢及PPAR[53]等脂肪细胞分化相关信号通路中的重要基因调节了牛脂肪细胞分化或脂肪代谢,影响了牛的脂肪沉积,为研究脂肪代谢疾病提供有用的信息。 影...
glycerol, and sugarcane bagasse. (A) Functional reconstruction of the main MAPK signaling pathways involved in pheromone response, cell wall stress, high osmolarity, and starvation inT. reesei. This analysis was performed using the KEGG MAPK signaling pathway in Yeast (https://www.genome...
MAPK/ERK signaling pathway is involved in RA anti-MM by GO and KEGG analysis Next, we used the DAVID database to perform GO and KEGG enrichment analysis of the corresponding targets and visualized the results. With GO enrichment analysis, we screened the top 10 biological processes (GO: BP)...
In the present study, KEGG analysis and Pathway-Act network of miRNA-targeted mRNA showed that MAPK signaling pathway was the hub pathway in dilated cardiomyopathy, which suggested the crucial role of MAPK signaling pathway in DCM. Interestingly, all dysregulated miRNAs associated with the MAPK ...
Yeast two-hybrid assay screened interacting proteins of STOML2, followed by bioinformatics analysis to predict biological function and signaling pathway of candidate proteins. Target protein with most functional similarity to STOML2 was validated with co-immunoprecipitation, and immunofluorescence were ...
Consequently, questions concerning the p38α MAPK deficiency promoted autophagic degradation of BACE1 must await clarification of the mechanisms through which BACE1 is delivered to the autophagic pathway. For transport to lysosomal degradation, BACE1 needs to be carried by its sorting adaptor proteins, ...
d DAVID analysis of canonical pathways enriched in genes bound by p38α showed that Wnt signaling pathway was one of the main signaling modules regulated by p38α. KEGG pathway is shown with p38α-bound promoters highlighted Full size image We validated p38α binding to the promoters of genes ...
(NS) have been linked to abnormalities in the regulation of the MAPK signaling pathway.50Moreover, the RAS/RAF/MAPK pathway is gaining attention as a potential target for the development of novel anti-inflammatory drugs, with implications for conditions like rheumatic arthritis (RA)51, ...
Tolerant MAPK signaling pathways. Numerous metabolic pathways have been reported affecting yeast tolerance by high throughput assays including transcriptome and proteome analysis5,27,28. How- ever, roles of MAPK pathway, especially in tolerance to toxic com- pounds liberated from biomass pretreatment, ...
In the present study, KEGG analysis and Pathway-Act network of miRNA-targeted mRNA showed that MAPK signaling pathway was the hub pathway in dilated cardiomyopathy, which suggested the crucial role of MAPK signaling pathway in DCM. Interestingly, all dysregulated miRNAs associated with the MAPK ...