基质金属蛋白酶-1丙二醛别嘌呤醇目的:观察缺血再灌注时的心肌P38MAPK、MMP-1表达及别嘌呤醇对其影响。方法:将36只中国大白兔分为3组,制作心肌缺血再灌注损伤模型。检测再灌注后心肌中P38MAPK、MMP-1的表达及MDA水平。结果:1.Sham组心肌P-P38表达极少且无MMP-1的表达。在I/R组心肌中有P-P38及MMP-1的表达,别...
2015-04-14上传 mapks通路在il-1β调控人牙周膜细胞表达mmp-1/-13中作用的的研究,牙周炎,牙周炎的治疗方法,牙周炎症状,牙周病,牙周炎怎么治疗,牙周炎吃什么药,牙周宁,牙周炎根治,甲硝唑治疗牙周炎 文档格式: .pdf 文档大小: 2.67M 文档页数: 76页 ...
胶原mRNA表达;ELISA法检测CFs细胞培养液中MMP-1的浓度.结果加入TWEAK干预后,促进了CFs增殖,Ⅰ型胶原蛋白及P-P38MAPK蛋白表达上调,Ⅰ型胶原mRNA和MMP-1表达上调.加入SB203580可抑制CFs增殖,部分抑制Ⅰ型胶原mRNA,Ⅰ型胶原蛋白,P-P38MAPK蛋白及MMP-1的表达.结论 TWEAK可通过P38MAPK途径促进CFs表达Ⅰ型胶原和MMP-1....
intermedia induced the expression of MMP-9 in human periodontal ligament (hPDL) cells. In this study, we further examined the effect of P. intermedia on MMP-1 (a collagenase that plays important roles in the initiation of collagen degradation) and its tissue inhibitor-TIMP-1 production. The ...
目的 观察柴胡皂苷d对体外培养的大鼠肝星状细胞系(HSC-T6)细胞MMP-1和TIMP-1表达的影响,并观察SSd对细胞MAPK和AP-1/NF-κB信号通路的调节作用,以及对MMP-1和TIMP-1蛋白表达的影响.方法采用ELISA方法检测细胞中MMP-1和TIMP-1的含量,Western Blot方法检测SSd作用下HSC-T6细胞中MAPK和AP-1/NF-κ B信号通路的...
In conclusion, Nrf2 could influence UVA-mediated MMP-1 upregulation through the MAPK/AP-1 signaling cascades. HPD and SFN may therefore represent promising antiphotoaging candidates. 展开 DOI: 10.1124/jpet.116.238048 被引量: 8 年份: 2017
Park S, Jung HH, Park YH, Ahn JS, Im YH (2011) ERK/MAPK pathways play critical roles in EGFR ligands-induced MMP1 expression. Biochem Biophys Res Commun 407:680–686Park S., Jung H. H., Park Y. H., Ahn J. S., Im Y.-H. ERK/MAPK pathways play critical roles in EGFR ...
The aim of this study was to elucidate the interaction between EGFR ligands and their signaling pathway and MMP expression which might be closely related with breast cancer pathogenesis. We investigated the effect of EGF ligands on the MMP1 expression in SK-BR3 cell lines using RT-PCR, Western...
产品全称:大鼠丝裂原活化蛋白激酶1(MAPK1)elisa试剂盒 英文名称:Rat mitogen activited protein kinase 1elisa Kit 货号:FT-101121E 检测范围:0.25-8ng/ml 规格:48T/96T 价格:敬请客户与我司取得联系获取实时报价 服务:可提供免费代测服务,以及产品说明书和技术指导等 ...
目的研究白介素-1β(Interleukin-1β,IL-1β)对人膝关节滑膜细胞基质金属蛋白酶-2(Matrixmetalloproteinase-2,MMP-2)活性的影响及MAPK和NF-κB信号通路抑制剂对该过程的影响。方法用不同浓度的IL-1β处理体外培养的滑膜细胞72h,明胶酶谱法检测细胞培养液中MMP-2的活性;选取10ng/ml的IL-1β单独或分别与4种信...