结果 0~40μM肉桂醛对成纤维细胞的活性无明显影响(P均0.05).肉桂醛能抑制UVA照射后成纤维细胞MAPK信号蛋白ERK,JNK,p38的活化,其也能抑制成纤维细胞表达MMP-1和MMP-3,且各浓度间作用差异均有统计学意义(P均0.05).结论肉桂醛可能通过抑制UVA照射后成纤维细胞MAPK信号蛋白的活化来抑制MMP-1和MMP-3的表达,减少...
胶原mRNA表达;ELISA法检测CFs细胞培养液中MMP-1的浓度.结果加入TWEAK干预后,促进了CFs增殖,Ⅰ型胶原蛋白及P-P38MAPK蛋白表达上调,Ⅰ型胶原mRNA和MMP-1表达上调.加入SB203580可抑制CFs增殖,部分抑制Ⅰ型胶原mRNA,Ⅰ型胶原蛋白,P-P38MAPK蛋白及MMP-1的表达.结论 TWEAK可通过P38MAPK途径促进CFs表达Ⅰ型胶原和MMP-1....
ERK/MAPK pathways play critical roles in EGFR ligands-induced MMP1 expression[J] . Sarah Park,Hae Hyun Jung,Yeon Hee Park,Jin Seok Ahn,Young-Hyuck Im.Biochemical and Biophysical Research Communications . 2011 (4)Park S,Jung H H,Park Y H. ERK/MAPK pathways play critical roles in EGFR ...
NF50E treatment inhibited UVB-induced collagen degradation as well as MMP-1 and IL-1β expressions and significantly stimulated SIRT1 expression. Furthermore, the extract treatment markedly suppressed the activation of NF-κB and AP-1 (p-c-Jun) by deactivating the p38 and JNK proteins. Taken ...
通过实验探究P38MAPK信号通路对高糖诱导的肾小球系膜细胞MMP-9和TIMP-1表达的影响。 研究内容及方法: 1.绘制实验流程图,设计实验方案。 2.培养肾小球系膜细胞至合适密度。 3.将细胞分为四组,分别为正常组、高糖组、高糖+P38MAPK激活剂组和高糖+P38MAPK抑制剂组。 4.观察各组细胞形态、增殖情况和活性变化。 5...
According to the data from this investigation, the augmented expression of the MMP-9 gene in these patients may be caused by genetic polymorphisms or inflammatory factors involved in the pathogenesis of cerebral hemorrhage. It is conceivable that the impact of this could be lessened by utilizing ...
目的:探讨p38丝裂原激活蛋白激酶(p38 MAPK)信号通路及其特异性抑制剂SB203580在气道炎症,黏液高分泌中的作用,阐明p38MAPK,基质金属蛋白酶-9(MMP-9)在黏液高分 泌与黏蛋白基因转录中的相互作用机制. 方法:成年雄性小鼠64只,实验随机分为4组:生理盐水对照组(NS组),SB203580对照组(SB组),丙烯醛模型组(Acro组),...
此外,血清胶原寡聚基质蛋白(COMP)、金属蛋白酶(MMP)-3和促炎细胞因子水平在来自secoiridoids喂养的动物的爪子中得到改善。丝裂原活化蛋白激酶(MAPK)和核转录因子-κ-B(NF-κB)激活显着下调,而核因子E2相关因子2(Nrf2)和血红素加氧酶-1(HO-1)在那些喂食OL和Per-OL饮食的小鼠中,蛋白质表达上调。我们得出结论,...
目的研究白介素-1β(Interleukin-1β,IL-1β)对人膝关节滑膜细胞基质金属蛋白酶-2(Matrixmetalloproteinase-2,MMP-2)活性的影响及MAPK和NF-κB信号通路抑制剂对该过程的影响。方法用不同浓度的IL-1β处理体外培养的滑膜细胞72h,明胶酶谱法检测细胞培养液中MMP-2的活性;选取10ng/ml的IL-1β单独或分别与4种信...
脂联素通过激活p38MAPK信号通路调节大鼠肝星状细胞MMP-13及TIMP-1表达