Locked in antagonistic rivalry with neighbouring powers, North Korea has staked its future on the development of nuclear weapons, to the outrage of the international community. The Kim family's dominance of the DPRK since 1948 has confounded its critics and frustrated its allies in equal measure....
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As an E3 ligase, RNF8 has been shown to promote the formation of K63-, K48-, and K11-linked polyubiquitin chains when coupled with E2s such as UBC13, UBCH8, UbcH6, UBE2E3, and UBE2S, respectively. This ubiquitination of RNF8-interacting targets contributes to their nuclear translocation,...
We detected SEPs predominantly in the cytoplasm (n = 138), and interestingly, we also identified 131 SEPs in the nuclear compartment, which included a disproportionately large number of uORF-encoded SEPs (Figure 6C; Table S10). The host genes of these SEPs encode transcription factors and ot...
As expected, we observe significant induction of nuclear foci formation for all the six measured DDR proteins upon gamma irradiation (Fig. 3c,d and Supplementary Fig. 6c–f). In addition, we observed the expected significant enrichment of nuclear foci that function in the homologous recombination ...
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War II, the city has been rebuilt and is significant as a spiritual centre for movements to ban nuclear weapons. Nagasaki, JapanPortion of the harbour at Nagasaki, Nagasaki prefecture, Kyushu, Japan. Nagasaki is an important tourist centre; its industry is still based upon its large shipyards,...
Hiroshima has become a spiritual centre of the peace movement for the banning of nuclear weapons. In 1947 the Atomic Bomb Casualty Commission (since 1975 the Radiation Effects Research Foundation) began to conduct medical and biological research on the effects of radiation in Hiroshima. A number of...
in part due to coalition air strikes, which destroyed chemical stocks as well as aircraft and artillery delivery systems. Another likely consideration for Saddam and Iraqi commanders was the very real possibility that Israel would respond to any chemical attack on its cities by utilizing itsnuclear ...