Arthritis in MRL/1pr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains ObjectiveTo clarify the mode of inheritance and the genome origins of arthritis in a lupus-prone strain of mice, MRL/MpJ, bearing a Fas deletion mutant gen...
BACKGROUND: Endothelial dysfunction may play a pathophysiological role in the development of atherosclerosis in subjects with type 1 diabetes. We examined ... Mikko J Jrvisalo,M Raitakari,JO Toikka,... - 《Circulation》 被引量: 838发表: 2004年 Genomewide Search for Type 2 Diabetes Mellitus ...
Manifestation of carcinogenesis as a stochastic process on the basis of an altered mitochondrial genome. Arch. Toxicol. 1981; 48 :89–125.Neubert D, Hopfenmuller W, Fuchs G. Manifestation of carcinogenesis as a stochastic process on the basis of an altered mitochondrial genome. Arch Toxicol. ...
Bacterial nanotubes are membranous structures that have been reported to function as conduits between cells to exchange DNA, proteins, and nutrients. Here, we investigate the morphology and formation of bacterial nanotubes using Bacillus subtilis. We sho
Therefore, we conclude that a subset of patients with fetal death may have endured a breakdown of maternal-fetal tolerance, which cannot be attributed to microorganisms in the amniotic cavity. Keywords: Amniotic fluid; bacteria; chorioamnionitis; chronic deciduitis; chronic inflammation; CXCL10/IP-...
Construction of an AFLP genetic map with nearly complete genome coverage in Pinus taeda De novo construction of complete genetic linkage maps requires large mapping populations, large numbers of genetic markers, and efficient algorithms for o... DL Remington,RW Whetten,BH Liu,... - 《Theoretical ...
Induction of various autoantibodies by mutant gene lpr in several strains of mice. This indicates that the action of the lpr gene on the development of autoantibody response does not require the particular abnormalities of the MRL genome. The differences in amounts and types of autoantibodies among...
The WHO confirmed that the outbreak of the coronavirus epidemic was associated with the Huanan South China Seafood Marketplace, but no specific animal association was identified [6]. Scientists immediately started to research the source of the new coronavirus, and the first genome of COVID-19 was...
Ankylosing spondylitis is a male-predominant disease and previous study revealed that estrogens have an anti-inflammatory effect on the spondyloarthritis (SpA) manifestations in zymosan-induced SKG mice. This study aimed to evaluate the effect of selecti
Detection of Catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE marker in the same region of the genome among families with thrombocytopenia, a clinical manifestation associated with severe lupus in SLE affec...