A rock or stone is not a subject that, of itself, may interest a philosopher to study; but, when he comes to see the necessity of those hard bodies, in the constitution of this earth, or for the permanency of the land on which we dwell, and when he finds that there are means wise...
Rare diseases are usually genetic, chronic and incurable disorders with a relatively low incidence. Developments in the diagnosis and management of rare diseases have been relatively slow due to a lack of sufficient profit motivation and market to attrac
a large number of flagella and a single membranous structure, a nanotube, which was the typical number of NTs per cell (when present). The rare terminal structures were also occasionally detected by this method. It is important to note that the SIM approach required no cell fixation (unlike ...
Using serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree building, we show two distinct types of tumor evolution in p53-mutant driven mouse models. Malignant gliomas/GBMs grow as a single mass (Type 1) and multifocal masses (Type 2)...
Ankylosing spondylitis is a male-predominant disease and previous study revealed that estrogens have an anti-inflammatory effect on the spondyloarthritis (SpA) manifestations in zymosan-induced SKG mice. This study aimed to evaluate the effect of selecti
is highly variable, depending on the ethnic background. HLA class I alleles, e.g.,A*24, andB*39, also contribute to the diabetes risk [18]. In adulthood, besides HLA genes, other genes gain relevance. Genome-wide association analyses of adult-onset T1D yielded more than 50 non-HLA ...