Management of phenytoin toxicity in palliative care.A letter to the editor is presented in response to the article "A case of phenytoin toxicity in a patient with advanced lung cancer," by Jenkins A. in the year 2006 issue.BajwahStChristopher'sSabrinaStChristopher'sEBSCO_AspPalliative Medicine...
The widespread use of phenytoin results in frequent accidental and intentional toxicity. Metabolism is enzymatic and can be described by Michaelis-Menten kinetics. This results in an increased half-life in overdose situations and a protracted clinical course which may last a week or more. The primar...
Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW (2009) Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. J Neuro-Oncol 93...
Clinical Features and Management of Poisoning Due to Phenytoin The widespread use of phenytoin results in frequent accidental and intentional toxicity. Metabolism is enzymatic and can be described by Michaelis-Menten k... JR Larsen,LS Larsen - 《Medical Toxicology & Adverse Drug Experience》 被引量...
report a patients with mesial temporal lobe sclerosis with interictal affective-somatoform (dysphoric) disorders who was never treated for psychiatric manifestations, and who deliberately took a massive dose of phenytoin and phenobarbitone with a motive of suicide, resulting in severe combined toxicity....
Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We disc
Aneurysmal subarachnoid haemorrhage (aSAH) presents a challenge to clinicians because of its multisystem effects. Advancements in computed tomography (CT), endovascular treatments, and neurocritical care have contributed to declining mortality rates. The
Metabolized by CYP3A4: caution with inhibitors (e.g., verapamil, diltiazem, ketoconazole, macrolide antibiotics, protease inhibitors, grapefruit juice) and inducers (e.g., rifampin, phenobarbital, phenytoin) Quinidine • 324–648 mg every 8 h • Prolonged QT interval • Diarrhea • Inhibit...
The neurotoxicity of misonidazole: potential modifying role of phenytoin sodium and dexamethasone. British Journal of Radiology 53: 172–173, 1980 PubMed CAS Google Scholar Weiss HD, Walker MD, Wiernik PH. Neurotoxicity of commonly used antineoplastic agents. New England Journal of Medicine 291: ...
Management of severe skin reactions to drugs should require admission to a burn unit, where patients should be placed in warmed air-fluidised beds, receive excellent nursing care, analgesics and tranquillisers. Peeling necrotic epidermis should be removed and denuded dermis covered with biological graf...