Once fatty acids are taken up by the cardiomyocyte (bound to fatty acid binding protein, FABP), fatty acyl CoA synthase (FACS) activates fatty acids to long-chain acyl CoA. This long-chain acyl CoA is either used for complex lipid synthesis (triacylglycerol, phospholipids, sphingolipids, and ...
Bacterial fatty acid synthesis in Escherichia coli is initiated by the condensation of an acetyl-CoA with a malonyl-acyl carrier protein (ACP) by the β-ketoacyl-ACP synthase III enzyme, FabH. E. coliΔfabH knockout strains are viable because of the yiiD gene that allows FabH-independent...
Fatty acid synthase (FAS) inhibition initiates selective apoptosis of cancer cells both in vivo and in vitro, which may involve malonyl-CoA metabolism. These findings have led to the exploration of malonyl-CoA decarboxylase (MCD) as a potential novel target for cancer treatment. MCD regulates the...
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CHS catlyze the reaction of malonyl-coA and coumaroyl-coA to chalcone, and is the first enzyme that leads to the synthesis of flavonoids. Regulation Mechanism of Chlorogenic Acid Accumulation during the Floral Organ Development of Lonicera confusa Other intermediary metabolites of fatty acid metabolism...
The cessation of phospholipid biosynthesis by the in-hibition of the -glycerol-3-phosphate acyltransferase using a mutant led to an accumulation of long chain acyl-acyl carrier proteins (acyl-ACP) and the concomitant inhibition of fatty acid biosynthesis in . Malonyl-CoA did not accumulate when ph...
Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay. The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carn...
Malonyl-CoA DrugBank Accession Number DB04524 Background A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. Small Molecule Groups Experimental Structure Download Similar Structures ...
Examines the mechanism of acyl transfer by the Streptomyces coelicolor malonyl-CoA:acyl carrier protein (ACP) transacylase (MAT). Similarities between primary amino acid sequences of the proteins and crystal structure of Eschirichia coli MAT; Use of site-directed mutagenesis and biochemical analysis;...
Here we show that, in rats fed a high-fat diet, whole-animal, muscle and liver insulin resistance is ameliorated following hepatic overexpression of malonyl–coenzyme A (CoA) decarboxylase (MCD), an enzyme that affects lipid partitioning. MCD overexpression decreased circulating free fatty acid (...