New reactions in the crotonase superfamily: Structure of methylmalonyl CoA decarboxylase from... Examines the molecular structure of methylmalonyl co-enzyme A (CoA) decarboxylase (MMCD) in the Escherichia coli. Evidence for an indirect involvement of M... Benning,Matthew,M.,... - 《Biochemistry...
Evidence is also presented that fatty acids containing straight and branched regions can be generated by the fatty acid synthetase from the rat and goose, from methylmalonyl-CoA in the presence of malonyl-CoA or other precursors of n-fatty acids. These results provide support for the hypothesis ...
Type I modular polyketide synthases assemble diverse bioactive natural products. Such multienzymes typically use malonyl and methylmalonyl-CoA building blocks for polyketide chain assembly. However, in several cases more exotic alkylmalonyl-CoA extender
methylmalonyl CoA甲基丙二酸单酰辅酶A methylmalonyl【化】 甲基丙二酰; 甲基丙二酰基; 甲基丙二酸单酰; 甲基丙二酸单酰基 CoA【化】 辅酶A 【医】 辅酶A COA=Change of Assignment 改变任务 Committee on Accreditation 鉴定委员会([美] ALA) Coa=Change of Assignment 改变任务 Committee on Accreditation 鉴...
网络变位酶;脢变位脢 网络释义
The residual methylmalonyl-CoA remaining after fatty acid synthetase reaction on (R,S)-methylmalonyl-CoA was also racemic. These results show that: (a) the decarboxylase is stereospecific, (b) replacement of the carboxyl group by hydrogen occurs with retention of configuration, (c) acetyl-CoA ...
The decarboxylase showed a pH optimum near 8.5–9.0 and a Km of 0.33 mM, decarboxylated neither malonic acid nor methylmalonyl-CoA and was inhibited by thiol directed reagents but not by avidin. Sucrose density gradient centrifugation of the gland homogenate showed that the major peak of ...
Such multienzymes typically use malonyl and methylmalonyl-CoA building blocks for polyketide chain assembly. However, in several cases more exotic alkylmalonyl-CoA extender units are also known to be incorporated. In all examples studied to date, such unusual extender units are biosynthesized via ...
The malonyl-CoA synthetase is used in the mfr. of a diagnostic drug for a methylmalonyl acid uria.KIM, YU - SAMCHAE, HO - JUNKANG, SANG - WONKWON, SON - JONGHONG, SONG - YU