Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous...
which is based on contracture of muscle fibres in the presence of halothane or caffeine. Two widely used forms of this test have been developed; one by the European Malignant Hyperthermia group (EMHG) and the other by the North American Malignant Hyperthermia Group, Caffeine Halothane Contracture...
malignant hyperthermia crisisMalignant hyperthermia (MH) is a life-threatening condition characterized by signs of hypermetabolism during general anaesthesia. There is a wide variability in the magnitude of these signs. Early recognition and immediate management are essential in preventing morbidity and ...
North American Malignant Hyperthermia Registry; NGS: Next Generation Sequencing; NMS: Neuroleptic Malignant Syndrome; OMIM: Online Mendelian Inheritance in Man; Orai1: Gene encoding ORA1 calcium release-activated calcium modulator 1; PolyPhen: Polymorphism Prediction; Pmut: Pathogen Mutation Prediction; SE...
The phenotypes of both syndromes overlap with other syndromes that have a clear genetic background, in particular RYR1-related malignant hyperthermia. Through a literature review, performed according to the PRISMA guidelines, we aimed to report the clinical features of both syndromes, and the results...
Kalow W. Inheritance of malignant hyperthermia: a review of published data. In: Britt BA (Editor), Malignant hyperthermia . Amsterdam: Martinus-Nijhoff; 1987. p 155-179.Kalow W (1987) Inheritance of malignant hyperthermia- a review of published data. In: Malignant hyperthermia Britt BA (ed) ...
A center for the diagnosis and research for malignant hyperthermia is established within the Research Division of the Department of Anesthesiology at the University of Texas Medical Branch, Galveston, Texas. In this Research Conference we define malignant hyperthermia, present its brief history, and ...
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxant succin
Malignant hyperthermia is a genetically inherited condition in many cases. The pattern of inheritance appears to be that of autosomal dominance with reduced penetrance and variable expressivity. The condition is not manifested in infancy or old age. The possible association with musculo-skeletal disease...