This was to gain an insight into how the application of the model may enrich the clinical utility of an EHR database. Further details are provided in Additional File 1. Our model enhances data granularity by extracting nuanced symptom-specific insights, such as anhedonia and suicidal ideation, ...
Background Previous studies have found qualitative structural and functional brain changes in major depressive disorder (MDD) patients. However, most studies ignored the complementarity of multisequence MRI neuroimaging features and cannot determine accurate biomarkers. Purpose To evaluate machine‐learning ...
Major Depressive Disorder (MDD) is a debilitating condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest in daily activities. Understanding its underlying causes and effective treatments is crucial for patient well-being. The Journal of Clinical Psychiatry provides...
Jackson HJBurgess PM Personality disorders in the community: results from the Australian National Survey of Mental Health and Wellbeing. Part III, relationships between specific type of personality disorder, Axis I mental health disorders and physical conditions with disability and health consultations. ...
32 Recent studies revealed that gender specific genomic differences in MDD patients, the downregulation of the MDD-related gene Dusp6 in females leads to an increased susceptibility to stress, but this expression is not present in male mice.33 In addition, studies of drug gene interactions, ...
Driving Behavior Outcomes Across Drivers With and Without Major Depressive Disorder, Where Each Variable Represents the Mean Number per Trip or Summary per Month (Addition of Total Medication Use) eTable 3. Description of the GPS-Based Driving Features Supplement 2. Nonauthor Collaborat...
increased gut dysbiosis with a specific enterotype, heightened activation markers on T cells, and elevated levels of whole blood stimulated (LPS + PHA) in vitro production of cytokines, chemokines, and growth factors (Almulla et al., 2023; Maes et al., 2022; Maes et al., 2023a; Maes et...
Long conceptualized as distinct diagnostic categories, major psychiatric disorders (MPDs), consisting of schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD), share substantial core features as implicated by converging lines of evidence from genetic, molecular, histological, ...
observedamong patients with major depression may contribute to their cognitive deficits.It is conceivable, however, that a mechanism specific for depression (eg,abnormal aminergic modulation of prefrontal structures) may also produce impairmentin executive functioning as observed in the present group of ...
Clinical features of bipolar depression versus major depressive disorder in large multicenter trials. Am J Psychiatry. 2006;163(2):225-231. PubMedGoogle ScholarCrossref 5. Olfson M, Marcus SC, Druss B, Elinson L, Tanielian T, Pincus HA. National trends in the outpatient treatment of ...