Mucosal-associated invariant T (MAIT) cells, a versatile population of innate immune T lymphocytes, have a crucial function in the response to infection and tumors. This study investigated the distribution of MAIT cells in COPD-associated NSCLC and their involvement in the immune response. Methods ...
which are expressed on MAIT cells from blood, liver, and other mucosal tissues.8,18,24–26 The MAIT cells from the endometrium, cervix, and blood displayed a universal expression of these markers, which was distinct from conventional CD8 þ and CD4 þ T cells (Supplementary Figure 1b)....
Markers and makers of NKT17 cells Article Open access 01 June 2023 A multilayered immune system through the lens of unconventional T cells Article 21 July 2021 A guide to thymic selection of T cells Article 18 July 2023 References Godfrey, D. I. et al. The burgeoning family of uncon...
Figure 1. MAIT cells express tissue-specific chemokine receptors and are abundant in the liver. (A) Representative staining for indicated activation markers, chemokine receptors, and NK receptors on CD4+ (green) or CD8β+ (blue) T cells (CD3+γδ−) and MAIT cells (CD3+γδ−CD4−CD8...
(A) Representative flow cytometry plots of T cells (TCRβ+) expressing MR1-5-OP-RU and Bcl6. (B) MFI fold change compared with D0 mice of TFH markers ICOS, CXCR5, and FR4 expressed by MAIT cells. (C) Frequency of conventional TFH (B220− TCRβ+ CD4+ CD44hi Bcl6+ PD-1+) an...
In a sub-cohort in which we interrogated ascitic MAIT cells for functional impairments, several exhaustion markers, most notably VISTA, were present on the surface. However, ascitic MAIT cells were capable of producing IFN-γ, TNF-α and granzyme B, but neither IL-17A nor IL-10, in ...
MR1-GFP localizes to endosomal compartments with late endosome and lysosome markers. BEAS-2B cells were transfected with pCI:MR1-GFP and incubated for 30 hours. One hour after transfection, cells were incubated with the lysosome Organelle light reagent. Cells were imaged live every 5 seconds for...
Most T cells only work in the person who made them. Your T cells fight threats by responding to molecular fragments that belong to a pathogen—but only when these molecules are bound with markers that come from your own tissues. Your influenza-fighting T cells can't help your neighbor, and...
IFNg, interferon-g; MAITs, mucosal-associated invariant T cells; MR1, major histocompatibility complex related protein 1; TNFa, tumor necrosis factor-a. T-cell memory markers differ between the two species, we find that macaque MAITs exhibit a spectrum of memory pheno- types largely dependent ...
OMIP 071: A 31-Parameter Flow Cytometry Panel for In-Depth Immunophenotyping of Human T-Cell Subsets Using Surface Markers Dissecting the functional diversity of T cells is critical in elucidating mechanisms and in developing therapies for various diseases. Here, we designed a ... SR Wang,N Zho...