参考文献 Alves de Lima, K., J. Rustenhoven and J. Kipnis (2020). "Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease." Annu Rev Immunol 38: 597-620. Hinks, T. S. C. and X. W. Zhang (2020). "MAIT Cell Activation and Functions...
参考文献 Alves de Lima, K., J. Rustenhoven and J. Kipnis (2020). "Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease." Annu Rev Immunol 38: 597-620. Hinks, T. S. C. and X. W. Zhang (2020). "MAIT Cell Activation and Functions...
Alves de Lima, K., J. Rustenhoven and J. Kipnis (2020). "Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease." Annu Rev Immunol 38: 597-620. Hinks, T. S. C. and X. W. Zhang (2020). "MAIT Cell Activation and Functions." Front...
We also identified a monocyte/macrophage interferon (IFN)-α–IL-18 cytokine shift and the ability of infected macrophages to induce the cytotoxicity of MAIT cells in an MR1-dependent manner. Together, our results suggest that altered MAIT cell functions due to IFN-α–IL-18 imbalance ...
2019年9月17日,牛津大学Nuffield医学院Paul Klenerman教授课题组(共同一作为冷天祺、Hossain Delowar Akther和Carl-Philipp Hackstein博士)在Cell Reports发表题为TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector funct...
However, the mechanism of MAIT cell activation in IBD and the role of these activated MAIT cells in disease pathogenesis have not been fully elucidated, yet (Tominaga et al., 2017). MAIT cells also exert protective functions during homeostasis at the barrier sites of the human body (Hinks ...
et al. Shared and distinct phenotypes and functions of human CD161++ Vα7.2+ T cell subsets. Front. Immunol. 8, 1031 (2017). PubMed PubMed Central Google Scholar Tang, X. Z. et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J. ...
MAIT cell effector functions include secretion of inflammatory cytokines, such as GM-CSF, IFN-γ, TNF and IL-17A and of cytotoxic molecules like granzyme B and perforin, as well as maintaining barrier integrity and participating in tissue repair and wound healing16,17,18,19,20. Recent transcrip...
Zhang MAIT Cell Activation and Functions Front. Immunol., 11 (2020), Article 1014, 10.3389/fimmu.2020.01014 View in ScopusGoogle Scholar 38 H. Wang, C. D'Souza, X.Y. Lim, L. Kostenko, T.J. Pediongco, S.B.G. Eckle, B.S. Meehan, M. Shi, N. Wang, S. Li, et al. MAIT ...
Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection ag