[1].MAIT cells mediate functions that link innate and acquired immunity in a broad spectrum of diseases,including infection,cancer,allergy,and autoimmunity[2].MAIT cells are abundant in human nonmucosal tissues,where they account for up to 10%of blood T cells and 45%of liver T cells,but are much less abundant in mice...
T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the best studied of the T cell subsets, but ‘unconventional’ T cells have emerged as being more abundant and influentia...
iNKT cells produce the cytokines IFN-gamma, IL-4, IL-13, and IL-17 in effector tissues suggesting that iNKT cells are able to serve various functions during an immune response.18–23 1Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA and 2Department of ...
αβ T cell development is initiated when immature progenitor cells migrate from the fetal liver or adult bone marrow to the thymus, where they undergo receptor-driven differentiation programs that test proper rearrangement and function of the TCRβ and TCRα chains. ...
cells receive further instructional cues to generate different T-cell sublineages, which together possess diverse immunological functions to provide host immunity. Over the years, numerous studies have contributed to a greater understanding of key thymic signals that govern T-cell differentiation and ...
Innate-like (also termed unconventional or invariant) T cells include γδT cells, NKT cells, and MAIT cells. Like conventional αβT cells they recognize antigen specifically with the TCR, which distinguishes them from ILCs. Their TCR repertoire is, however, of limited diversity compared to con...
in SRSF1-deficient DP and iNKT cells. Strikingly, ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1. Furthermore, we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury upon α-GalCer and Con A induction. Our ...
Increasing evidences have found that the clinical importance of the interaction between hypoxia and immune status in gastric cancer microenvironment. However, reliable prognostic signatures based on combination of hypoxia and immune status have not been
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge Article 24 June 2020 Introduction T cells comprise two major lineages, αβ or γδ, broadly defined by the T cell antigen receptor (TCR) complex they express. These lineages arise from a commo...
Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell death control mechanisms of mucosal-associated invariant T (MAIT) cells, a specialized T cell population, are largely unknown.