Additionally, the use of CorreGene's SMART-TCR system has facilitated the acquisition of TCRs with high affinities in the pico-molar range. By leveraging CR62 and a high-affinity TCR, we have conceptualized the TCR-based T-cell engager, CRPA1A2. Comprehensive preclinical assessments have been...
MAGE‑A1特异性TCR及TCR‑T因此有希望成为具有高抗肿瘤疗效和低脱靶效应的癌症疗法。发明内容 [0006]根据本发明的第一方面,提供一种分离的特异性结合主要组织兼容性复合体(MHC)/MAGE‑A1表位复合体的肿瘤特异性T细胞受体(TCR)或其抗原结合结构域, 所述肿瘤特异性TCR包括: TCRα链, 所述TCRα链包含具有SEQ ...
TCR-based T-cell engagers, such as Tebentafusp, overcome this hurdle by targeting intracellular protein-derived peptides presented on cancer cell surfaces via HLA, enabling precise cytotoxic T cell attacks. Notably, Tebentafusp has shown significant clinical benefits by improving survival rates in ...
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors. Cancer Immunol Immunother 2013;62:773–785. 43 van der Bruggen P, Traversari C, Chomez P, et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science...
Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells... - 《Science Translational Medicine》 被引量: 0发表: 2013年 Cardiovascular Toxicity and Titin Cross-Reactivity of Affinity-Enhanced TCR-Engineered T Cells Against HLA-...
The present invention relates to an isolated T cell receptor (TCR) specific for a MAGEA1- derived peptide and to a polypeptide comprising a functional portion of the TCR. Further implicated are a multivalent TCR complex, a nucleic acid encoding a TCR, a cell expressing the TCR and a ...
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as ...
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as ...
Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR [alpha][beta] gene transfer requires CD8[alpha]. Gene Ther. 2005; 12:140-146.Willemsen R, Ronteltap C, Heuveling M, Debets R, Bolhuis R. Redirecting human CD4+ T lymphocytes to the MHC...
The present invention , a) HLA-A1 to the relevant to melanoma antigen family A (MAGE A) -3, or b) in relation to HLA-Cw7 and having antigenic specificity for MAGE-A12, has been isolated or purified I provide T cell receptor (TCR). The present invention , related polypeptides and ...