To date, clinical investigations of TCR-T cell therapies have targeted one antigen/HLA at a time and have produced encouraging but partial response rates with limited durations. While heterogeneity of antigen expression is appreciated as a likely driver of patient relapse, the contribution of HLA ...
225 Optimal-affinity MAGE-A1-specific T cell receptors (TCRs) generated using the humanized TCR-transgenic mouse platform HuTCR are superior to human donor-derived TCRs 使用人源化TCR转基因小鼠平台HuTCR产生的225种最佳亲和力MAGE-A1特异性T细胞受体(TCR)优于人供体来源的TCR...
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced TCR-engineered T cells against HLA-A1 restricted MAGE-A3 antigen. Mol Ther. 2013; ... MV Maus,GP Linette,EA Stadtmauer,... - Meeting of the American-society-of-gene-and-cell-therapy 被引量: 473发表: 2013年 Structurally...
Additionally, the use of CorreGene's SMART-TCR system has facilitated the acquisition of TCRs with high affinities in the pico-molar range. By leveraging CR62 and a high-affinity TCR, we have conceptualized the TCR-based T-cell engager, CRPA1A2. Comprehensive preclinical assessments have been...
The present invention relates to an isolated T cell receptor (TCR) specific for a MAGEA1- derived peptide and to a polypeptide comprising a functional portion of the TCR. Further implicated are a multivalent TCR complex, a nucleic acid encoding a TCR, a cell expressing the TCR and a ...
Redirecting human CD4+T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha. Gene Therapy 2005; 12(2) 140-146.Willemsen R, Ronteltap C, Heuveling M Debets R, Bolhuis R: Redirecting human CD4 + T lymphocytes to the MHC ...
The present invention , a) HLA-A1 to the relevant to melanoma antigen family A (MAGE A) -3, or b) in relation to HLA-Cw7 and having antigenic specificity for MAGE-A12, has been isolated or purified I provide T cell receptor (TCR). The present invention , related polypeptides and ...
Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR [alpha][beta] gene transfer requires CD8[alpha]. Gene Ther. 2005; 12:140-146.Willemsen R, Ronteltap C, Heuveling M, Debets R, Bolhuis R. Redirecting human CD4+ T lymphocytes to the MHC...
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as ...
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as ...