M1 and M2 macrophages’’clinicopathological significance in cutaneous melanoma. Falleni M,Savi F,Tosi D,et al. Melanoma research . 2017Falleni M, Savi F, Tosi D, Agape E, Cerri A, Moneghini L, et al. M1 and M2 macrophages' cl...
ability to polarize M2 macrophages into M1 macrophages. In summary, the lysosome not only is a place for cargo degradation but also plays crucial roles in regulating macrophage polarization. T-MPs, by virtue of their entry into lysosomes, can polarize tumor-associated macrophages into an M2 phenot...
The plasticity of the macrophages assists them to adaptin the microenvironment by changing the activation state ensuing in comprehensive classification and activation of M1 or M2 macrophages (Fig.2).54Consequently, through TLR and CLR recognition, the immune cells respond to invading microbes and rege...
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance As an essential component of innate immunity, macrophages have multiple functions in both inhibiting or promoting cell proliferation and tissue repair. Div... N Wang,H Liang,K Zen - 《Front Immunol》 被引量: 347发表: ...
Etoposide-induced cancer cell apoptosis was markedly reduced in the presence of THP-1 M2 macrophages, while apoptosis was increased in cells co-cultured with M1 macrophages. On the other hand, etoposide did not influence M1 or M2 polarization. Conclusions These results evidence for the first time...
LETM proteins play a role in the accumulation of mitochondrially encoded proteins in Arabidopsis thaliana and AtLETM2 displays parent of origin effects The Arabidopsis thaliana genome contains two genes with homology to the mitochondrial protein LETM1 (leucine zipper-EF-hand-containing transmembrane pro...
Thus, similarly to determine the effect of boron carbide preparations on the viability of M0, M1 and M2 bone marrow-derived macrophages after 72 h of incubation, the MTT assay was performed (Fig. 1C). Based on the obtained results, B4C 1 and B4C 2 concentrations causing 50% inhibition ...
Interestingly, adipocytes treated with M1 macrophages conditional medium (CDM) showed enhanced Ets1 expression (SuppFig. 2E), which is exactly opposite to the effect of M2 macrophages CDM. In addition, overexpression of Ets1 can significantly exacerbate the inhibitory effect of M1 macrophages on beig...
74 In addition, the growth factors GM-CSF and M-CSF, traditionally used to differentiate monocytes into dendritic cells or macrophages, have the ability alone to induce M1- and M2-like phenotypic changes, respectively.75 In fact, the phenotypes of macrophages can switch between different ...
Macrophage M1/M2 polarization and rheumatoid arthritis: a systematic review. Autoimmun Rev. 2019;18(11):102397. Article CAS PubMed Google Scholar Kim J, Kim HY, Song SY, Go S-H, Sohn HS, Baik S, et al. Synergistic oxygen generation and reactive oxygen species scavenging by Manganese ...