Macrophages in thehuman BAL fluid, which were negative for both M1/M2 surface markers, harbored a gene signature that was pro-inflammatory and suggested dysfunction in cellular homeostasis. These macrophages may contribute to the pathogenesis and manifestations of inflammatory lung diseases such as COPD.doi:10.1038/s41598-...
根据极化后巨噬细胞的表面标志物及其功能,将其分为M1型(经典活化)巨噬细胞和M2型(替代激活)巨噬细胞两种主要表型。切记,巨噬细胞macrophages的极化M1和M2是机体巨噬细胞调控平衡的两个跷跷板顶端,不是就M1或者就M2这么绝对,一定是两者并存,动态调整的状态。某个时相,某个条件,某个空间,某个生态位,可能以一种...
经典起源分类方法可将其分为组织驻留型巨噬细胞和单核细胞衍生型巨噬细胞。根据功能状态或者活化状态,分为M1型(经典活化)巨噬细胞和M2型(替代激活)巨噬细胞两种主要表型。 巨噬细胞就是人体免疫系统的巡警,作为机体的第一道防线,随时盯防,迅速出警。当巨噬细胞出现在血液里,被称为单核细胞,是血液里最大的白细胞...
Differentiation of monocytes occurs at the site of inflammation into the pro-inflammatory (M1, glycolytic) or anti-inflammatory (M2, oxidative) phenotype. Chronic disorders associated with low-grade inflammatory responses are characterized by presence of pro-inflammatory mediators that induce the ...
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polarization settin
We demonstrated that IL-10 expression may be much higher in LPS and IFN-γ induced M1macrophages than that in M2 macrophages and IL-10 cannot always be regarded a biomarker of M2 macrophages.Key words: Macrophage lipopolysaccharide interleukin inflammation markers前言巨噬细胞是免疫系统最重要的组成...
The bone marrow-derived macrophages (M0, M1 and M2) were placed in 96-well plates at a density of 0.15 × 105 cells/well. After 24 h, boron carbide preparations (B4C 1 and B4C 2) were added at concentrations in the range from 0.1 to 200 µg/ml and incubated for 72 h. ...
M1-polarizing conditions. Further analyses indicated that macrophages that express IL-13Rα1 also display surface markers associated with an M2 phenotype. In addition, the IL-13Rα1(+) macrophages were highly efficient in phagocytizing zymosan bioparticles both in vitro and in vivo, and ...
During the M1-to-M2 transition of macrophages the molecu- lar changes occurring can have profound effect on breast cancer cell behaviour; notably, the levels of the cytokines CSF-1 and CCL2 are elevated during this transition [16, 32]. CSF-1 and CCL2 are known mod- ulators of the fate...
M1 and M2 are classifications historically used to define macrophages activated in vitro as pro-inflammatory (when classically activated with IFNγ and lipopolysaccharide) or anti-inflammatory (when alternatively activated with IL-4 or IL-10), respectively. However, in vivo macrophages are highly speci...