Macrophages are innate immune cells first identified by Elia Metchnikoff in starfish hatchlings in 1882 when tangerine tree thistles were used, then inDaphnia magnaor essential water flea infested with fungal spores as the cells responsible for the cycle of phagocytosis of foreign materials. For this...
The use of cells as carriers for the delivery of nanoparticles is a promising approach in anticancer therapy, mainly due to their natural properties, such as biocompatibility and non-immunogenicity. Cellular carriers prevent the rapid degradation of nano
Ontogeny and homeostasis of CNS myeloid cells. Nat. Immunol. 18, 385–392 (2017). CAS PubMed Google Scholar Goldmann, T. et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17, 797–805 (2016). This work uses fate mapping and parabiosis...
Macrophages were first identified by Metchnikoff as a type of responding cells with phagocytic activity [21]. Later, it was presumed that they originated from the reticuloendothelial system, which supports the generation and differentiation of vascular endothelial cells [22]. This early concept, which...
Recently, type 1 innate lymphoid cells (T1-ILCs), including natural killer (NK) cells, have been reported to be involved in the AT immune response in obesity. Adipose T1-ILCs (AT1-ILCs) play a pathogenic role by promoting the production of proinflammatory M1 macrophages that underlie obesity-...
macrophages residing in the central nervous system (CNS) have become a focus of attention. The CNS has been considered unique for being immune-privileged, as the blood–brain barrier (BBB) acts as a roadblock, preventing microorganism entry and the influx of circulating immune cells [7]. CNS ...
Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung during allergic asthma, which
THP-1 monocytes were seeded in T25 flask at 2.5 × 106 cells/T25 and differentiated with PMA. After incubation with or without IL-4 and IL-13, cells were washed with cold PBS and detached with EDTA 5 mM. Cold PBS containing 5 % human heat inactivated serum (his) and 0.1 % NaN3 wa...
YFP+cells in the MG of newborn, 2 wk old and 5 wk old CX3CR1-YFP mice, when we administered a single dose of tamoxifen at E13.5 (Fig.1b). When backgated on the two different CD45+Siglec-F−CD11b+macrophage populations, we found that the YFP+cells fell almost exclusively into ...
Here, we report that, in areas of disturbed blood flow, aortic endothelial cells permanently and intimately associate with a population of specialized macrophages. These macrophages are recruited at birth from the closing ductus arteriosus and share the luminal surface with the endothelium, becoming ...