Macrophages in a tumor microenvironment have been characterized as M1- and M2-polarized subtypes. Here, we discovered the different macrophages' impacts on lung cancer cell A549. The M2a/M2c subtypes promoted A549 invasion and xenograft tumor growth. The M1 subtype suppressed angiogenesis. M1 ...
而在某些慢性炎症及特定急性验证进程中,M1/M2细胞类群比例失调,过度M1细胞类群激活会导致组织严重损伤,并导致后续更严重的炎症因子风暴等不良症状。 因此,在炎症疾病治疗中可以通过抑制M1细胞类群数目,提高M2细胞类型比例的方式对炎症开展治疗。 4.2、巨噬细胞亚型在肿瘤疾病中研究 肿瘤相关巨噬细胞(tumor associate macr...
致力于开发CAR-Macrophage疗法用以治疗肿瘤,直至2020年,他们发表研究性论文报道采用靶向HER2的CAR对巨噬细胞进行改造,并使用小鼠模型验证了CAR-Macrophage细胞对肿瘤的良好杀伤效果,并发现HER2-CAR-M能够将M2巨噬细胞转化为M1巨噬细胞,诱导炎症性肿瘤微环境,增强T细胞的抗肿瘤细胞毒性,因此这也体现了CAR...
因此，在炎症疾病治疗中可以通过抑制M1细胞类群数目，提高M2细胞类型比例的方式对炎症开展治疗。4.2、巨噬细胞亚型在肿瘤疾病中研究 肿瘤相关巨噬细胞（tumor associate macrophage，TAM）指被募集到肿瘤微环境中的巨噬细胞。早期研究认为巨噬细胞具有抑制肿瘤的作用，但是后续研究发现TAM能够通过抑制免疫反应，...
Anatomy of a discovery: M1 and M2 macrophages. Front. Immunol. 6, 212 (2015). Article PubMed PubMed Central Google Scholar Sica, A. et al. Autocrine production of IL-10 mediates defective IL-12 production and NF-κB activation in tumor-associated macrophages. J. Immunol. 164, 762–767...
Evaluating thePolarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in HumanCancer Tissue: Technicalities and Challenges in Routine Clinical Practice CarismaTherapeutics网站,https://carismatx.com/ 药品研发质量管理体系建立...
More importantly, exosomes secreted by MSCs could play a significant role in inhibiting M1 polarization and promoting M2 polarization to reduce inflammation. And the regulation of M2 polarization by MSC-derived exosomes could enhance skin wound healing [18]. MSCs can also promote polarization of M2 ...
Notably, XYT was found to suppress macrophage M1 polarization, while enhancing M2 polarization, ultimately benefitting cardiac function via LncSICRNT1 modulation. Furthermore, the study revealed LncSICRNT1 modulated Beclin-1 ubiquitination and restrained macrophage autophagy by targeting TRAF6 expression. ...
Although inflammatory (M1) macrophages can promote atherogenesis, IL-4-induced macrophages (M2) are regarded as atheroprotective because of their anti-inflammatory and pro-fibrotic homeostatic properties1. Previous in vitro studies with inhibitors suggested that Acly is involved in both inflammatory and ...
Tumor associated macrophages (TAMs) play a critical role in biology of various cancers, including breast cancer. In the current study, we defined "M1" macrophage and "M1"/"M2" ratio by transcriptomic signatures using xCell. We investigated the association between high level of "M1" macrophage ...