In this review, mechanisms underlying the distinct functional characterization of M1 and M2 macrophages are demonstrated to make sense of M1 and M2 as key regulators during cancer progression.doi:10.1186/s12935-021-02089-2Jiuyang LiuXiafei Geng...
1.Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022 Nov;21(11):799-820. doi: 10.1038/s41573-022-00520-5. Epub 2022 Aug 16. PMID: 35974096; PMCID: PMC9380983. 2....
Several recent studies have shown that M1 and M2 macrophages were distributed throughout human cancer tissues15,16. However, the exact effects of different TAM subtypes, such as M1 versus the differ- ent M2 subtypes, on the regulation of gene expression and modulation of the biological behaviors...
Nevertheless, the localization of M1 and M2 macrophages in the tumor had standard features and did not differ. A possible mechanism of the effect of microcalcifications on the polarization of macrophages is their support of chronic inflammation in cancer tissues and, thus, the development of pro-...
mRNA and protein expression of M1 and M2 markers confirmed the polarization of THP-1-derived macrophages, which provide a new, easy and well-characterized model of polarized human macrophages. Etoposide-induced cancer cell apoptosis was markedly reduced in the presence of THP-1 M2 macrophages, whil...
2022的一篇CELL文章:《Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer》就提到了里面的巨噬细胞可以分类成为2个: (1) TREM2+ macrophages expressing triggering receptor expressed by myeloid cells-2 (TREM2) and osteopontin (SPP1) genes, ...
[5] LI J, LI N, WANG J. M1 macrophage-derived exosome encapsulated cisplatin can enhance its anti-lung cancer effect[J]. Minerva Med, 2023, 114(5): 634-641. [6] REN J B, XU B J, REN J H, et al. The im...
In this review, we will summarize different microglial polarization states and provide evidence of M1/M2 activation states in cancer pain and morphine tolerance. We will also point out the potential of using microglia different activation states as therapeutic targets from cancer pain management to ...
2022年3月发表在cell上的一篇文章“Tissue-resident FOLR2+ macrophages associate with CD8+T cell infiltration in human breast cancer”,首先通过流式和单细胞测序分析确定了乳腺癌中TAMs的特征是表达APOE,然后通过单细胞测序分析将APOE+TAMs分为FOLR2+巨噬细胞和TREM+巨噬细胞两个亚群。其次,作者利用流式、Bulk...
2022的一篇CELL文章:《Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer》就提到了里面的巨噬细胞可以分类成为2个: (1) TREM2+ macrophages expressing triggering receptor expressed by myeloid cells-2 (TREM2) and osteopontin (SPP1) genes, ...