Objective: IL-1b is a leaderless cytokine with poorly known secretory mechanisms that is barely detectable in serum of patients, including those with an IL-1b-mediated disease such as systemic juvenile idiopathic arthritis (sJIA). Leukocyte microvesicles (MVs) may be a mechanis...
M2b macrophages: Activation by immune complexes, Toll-like receptor (TLR) ligands and IL-1b. Upon activation, this subtype releases pro- and anti-inflammatory cytokines TNF-α, IL-1b, IL-6, and IL-10. M2b macrophages function in the regulation of the immune r...
M2b macrophages: Activation by immune complexes, Toll-like receptor (TLR) ligands and IL-1b. Upon activation, this subtype releases pro- and anti-inflammatory cytokines TNF-α, IL-1b, IL-6, and IL-10. M2b macrophages function in the regulation of the immune r...
Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β in DM mice. IL-1β causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in ...
M1 macrophage polarization is driven by the transcription factors interferon regulatory factor 5 (IRF5) and nuclear factor-kappa B (NF-κB). Upon activation by IFN-γ or LPS, IRF5 and NF-κB translocate to the nucleus and promote the expression of pro-inflammatory cytokines, such as IL-1β...
B Expression of IL1B. Graphs show the expression values for each genotype at IL1B SNV rs1143634 for the four time points. Y axis—expression (CPM). X-axis—genotype. Colour of dots indicates disease status (red: affected with Crohn’s disease or ulcerative colitis; black: unaffected ...
Macrophage exposure to HCV induces inflammasome signaling of IL-1β and proinflammatory cytokine and chemokine expression.Amina A. NegashHilario J. RamosNanette CrochetDaryl T. Y. LauBrian DoehleNeven PapicDon A. DelkerJuandy JoAntonio Bertoletti...
Interleukin-1β (IL-1β) is one of the key pro-inflammatory mediators and its maturation is tightly controlled by the formation and activation of the inflammasome. The biological effects of IL-1β are mediated through IL-1 receptor (IL-1R). In this study, we investigated the influence of ...
Coupled with an LPS-induced increase in ACLY activity, enhanced production of acetyl-CoA drives histone acetylation and induction of the inflammatory genes Il6 and Il1b. As oxidation of carbon substrates in the TCA cycle depends on the availability of electron acceptors such as NAD+, the cyclic...
Interestingly, induction of the macrophage oxidative program was accompanied by an increase in the expression of PGC-1β mRNA (Figure 1B). Immunoblot analyses further verified that stimulation of bone marrow-derived or thioglycolate-elicited macrophages with IL-4 robustly induced the expression of PGC...