However, the loss of the immune system suppression by M1 and Th1 molecules will give benefit to fertility development of Mtb in the environment of immunity M2 / Th2. The results of this study showed that the dynamics of macrophages in tuberculosis disease is a balance o...
Macrophages have diverse phenotypes and functions due to differences in their origin, location and pathophysiological context. Although their main role in the liver has been described as immunoregulatory and detoxifying, changes in macrophage phenotypes, diversity, dynamics and function have been reported ...
Mice with increased macrophage expression of angiotensin converting enzyme (ACE), called ACE 10/10 mice, have a profound increase of macrophage function in response to diverse immune challenges including tumors, infection, atherosclerosis, and Alzheimer's disease. ACE 10/10 macrophages are highly effic...
This process is further complicated when analysing wounds because these macrophages can adopt different phenotypes in the wound [15,18,24,40]. Broadly speaking, phenotypes can be characterised by their function, with pro-inflflammatory macrophages that are often ...
We have reported previously that sympathectomy augments immune responses in mice and rats. In the present study, we show that ablation of the sympathetic nervous system augments macrophage function as measured by increased TNF secretion. We also show that a factor present in the sympathetic ganglia...
macrophage, type ofwhite blood cellthat helps eliminate foreign substances by engulfing foreign materials and initiating an immune response. Macrophages areconstituentsof the reticuloendothelial system (ormononuclear phagocyte system) and occur in almost all tissues of the body. In some instances, macroph...
RANKL also has a function in the immune system, where it is expressed by activated T cells and is thought to be involved in dendritic cell maturation. Receptor activator for nuclear factor-κB (RANK) is the receptor of RANKL. Both RANKL knockout mice and RANK knockout mice exhib...
To further investigate the effects of HA disks with different surface nano/micro-topographies on macrophage polarization and function, the gene expression of inflammation-related factors was determined by qRT-PCR. M1 phenotype markers (iNos, Ccr7, and Il1), M2 phenotype markers (Arg, Cd206, and...
Macrophage inflammatory cytokine production decreased in response to ivacaftor alone. In summary, ivacaftor and lumacaftor/ivacaftor have differential impacts on macrophage function with minimal changes observed in CF patients treated with lumacaftor/ivacaftor. Overall improvements in macrophage function in ...