Macrophages form ‘immunological synapses’ with CD4 T cells during MHC II dependent antigen presentation. These involve contact between the two cells via a number of interacting surface proteins including LFA-1 and ICAM-1 in addition to peptide loaded MHC interaction with the cognate TCR on CD4 T...
(2011). "CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice." Cell Immunol 266(2): 180-186.CD4 + T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice[J] . Tiffany Chan,Elisabeth A. Pek,Kathleen Huth,Ali A. ...
CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice. Cell Immunol. 266, 180-186.CHAN T, PEK EA, HUTH K,... T Chan,EA Pek,K Huth,... - 《Cellular Immunology》 被引量: 28发表: 2011年 CD4+ T-cells are important in regulating macrophage pol...
G. et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91–102 (2009). CAS PubMed PubMed Central Google Scholar Terabe, M. et al. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and ...
BCL6 inhibits CD4+Foxp3+ regulatory T cell trans‐differentiation into macrophage‐like cells via modulation of chromatin long‐range interactionsThe mechanisms underlying macrophage (M) heterogeneity and regulatory T cell (Treg) plasticity remain poorly determined. Here, we determined the mRNA ...
HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells. Martin et al., " HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells., " Abstract, J. Immunol., 152:330-342 (1994).HIV-1 infection of...
工程化免疫细胞疗法即通过基因工程技术改造不同免疫细胞后进行靶向性治疗,主要以TCR-T、CAR-X (T/NK/Macrophage/Treg) 等细胞疗法为代表。TCR-T (T细胞受体工程化T细胞, T-cell receptor engineered T cells) 利用基因编辑技术,将能特异性识别肿瘤抗原的TCR基因导入患者T细胞内,使其表达外源性TCR,从而具有特异性杀...
In situ hybridization and immunohistochemical analyses revealed that tissue macrophage in the lymph nodes, spleen, gastrointestinal tract, liver, and kidney sustain high plasma virus loads in the absence of CD4+T cells. Quantitative confocal immunofluorescence analysis indicated that greater than 95% of ...
No differences were found in the supernatant fluid of similar cultures of CD4+ T cells from both these species. Autologous (but not allogeneic) CD8+ T cells from SIV infected mangabeys and rhesus macaques inhibited SIV replication in vitro. The suppression appeared more marked in monocytes from ...
These findings provide a mechanism for the immune regulation in leishmaniasis and a means by which the two subsets of CD4+ T cells influence each other through their modulation of macrophage function.doi:10.1002/eji.1830190712Foo Y. Liew