Exogenous IL-22 administration, but not endogenous IL-17 neutralization, protects CD18−/− mice from lethal colitis.β2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin...
(Fig.2c). In addition, the deacetylase inhibitor TSA/NAM pretreatment significantly promoted the acetylation of Lys383 in Stat6 in murine primary macrophages (Fig.2d, e). To study the function of Lys383 acetylation in Stat6, we examined the effect of different Stat6 mutations on the ...
Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play vital roles in human diseases. We aimed to identify the effect of the lncRNA AGAP2 antisense RNA 1 (AGAP2-AS1)/miR-296/notch homolog protein 2 (NOTCH2) axis on the progression and radioresistance
此外,我们发现M2来源的外泌体诱导TAM介导的促迁移活性。通过质谱分析,我们发现整合素αMβ2(CD11b/CD18)在M2巨噬细胞源性外显体(M2 exos)中具有显著的特异性和高效性。阻断CD11b和/或CD18可显著降低M2-exos介导的HCC细胞转移。机制上,M2外显子介导CD11b/CD18的细胞间转移,激活受体HCC细胞中的MMP-9信号通路...
Taken together, these data suggest that macrophage HIF-2α would counteract the proinflammatory responses to relieve obesity-induced insulin resistance in adipose tissue. 展开 关键词: Animals Mice Adipose Tissue Macrophages Inflammation Insulin Resistance Obesity RNA, Small Interfering Basic Helix-Loop-...
However, the role of macrophage HIF-2α in NLRP3 inflammasome activation remains unclear. Here, we show that deficiency of HIF-2α in macrophages results in excessive activation of the NLRP3 inflammasome in a manner dependent on CPT1A-mediated enhancement of fatty acid oxidation (FAO). ...
Natural resistance-associated macrophage protein 2 ELISA Kit的详细说明书 检测范围:15.6-1000 pg/mL 使用:本试剂仅供科研使用 保存:2-8℃ 有效期:6个月 检测方法:ELISA 产品性状:96T/48T,盒装液体 贮藏条件:2-8°C ELISA试剂盒实验原理: ELISA是以免疫学反应为基础,将抗原、牽9体的特异性反应与酶对底物的...
To assess directly the role of oxidative stress on regulation of MIP-2 mRNA expression, macrophages were exposed to H 2 O 2 . MIP-2 mRNA levels had significantly increased after 1 hr exposure to 0·5 mm H 2 O 2 , were maximally increased after 4 hr and decreased after 6 hr. Co-...
Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease. Am J Physiol Lung Cell Mol Physiol 304: L162-L169, 2013. First published November 30, 2012; doi: 10.1152/ajplung.00182.2012.-Human rhinovirus (HRV)...
23, 24 Although transmembrane protease cascades likely regulate neural crest development through PAR2,14 it is clear that control of coagulation initiation by TF during embryonic development is also required, as demonstrated by the lethality of knockouts of the first Kunitz domain of TF pathway ...