report on an approach that integrates machine learning and high-throughput synthesis for the discovery of ionizable cationic lipids. The effort resulted in the identification of an ionizable cationic lipid that outperformed clinically approved lipids for LNP-mediated local and systemic mRNA delivery (...
Sophisticated delivery nanotechnology is a prerequisite for the successful therapeutic application of messenger RNA (mRNA), as it prevents premature degradation and ensures intracellular delivery. Among the various delivery platforms, lipid nanoparticle (LNP) technology has been clinically translated and deploy...
+6 LNP@mRNA 2025-01-20 9/450 2025-01-26 22:42 by 马原毛中特 [教师之家] 咨询一下,为什么基金委,科技厅喜欢在寒假让大家写本子,刚开学就要交 +13 艾克斯奥特曼 2025-01-22 15/750 2025-01-26 22:07 by willbuilder [教师之家] 有些核心论文也没多少新意,有些中标项目似乎不是很有价值 +...
To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid nanoparticle development that remains a bottleneck is identifying new ionizable lipids. Here we des
Identifying genetic drivers of chronic diseases is necessary for drug discovery. Here, we develop a machine learning-assisted genetic priority score, which we call ML-GPS, that incorporates genetic associations with predicted disease phenotypes to enhanc
LNPs,and mRNA molecules twined around the LNPs.In summary,the machine learning predictive model for LNP-based mRNA vaccines was first developed,validated by experiments,and further integrated with molecular modeling.The prediction model can be used for virtual screening of LNP formulations in the ...
These tools are part of the Industry 4.0 revolution, which plays a vital role in microparticle and microfluidics, alongside mRNA-LNP vaccines, and stability in advanced protein therapeutics.Area covered This study summarizes the application of ML tools in drug discovery, formulation development, and ...
Mathematical and Computational Applications Article Machine Learning-Based Sentiment Analysis for Twitter Accounts Ali Hasan 1, Sana Moin 1, Ahmad Karim 2 and Shahaboddin Shamshirband 3,4,* ID 1 Department of Computer Science, Air University, Multan Campus, Multan 60000, Pakistan; alihasan1520@...
mRNA vaccine manufacturing; in vitro transcription; lipid nano particles; continuous biomanufacturing; digital twins; machine learning; autonomous operation1. Introduction mRNA vaccines against SARS-CoV-2 were approved in 2020 through an accelerated process to limit the pandemic, which had restricted large...