A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J 2007;26:1129-39.Orlova VV, Choi EY, Xie C, et al.: A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J 2007, 26:1129-1139....
蛋白别名:antigen CD11b (p170); CD11 antigen-like family member B; CD11b; Cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; Integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); Leukocyte adhesion...
RO-Heparin Inhibits β2-Integrin(Mac-1)-mediated Neutrophils AdhesionRO-Heparin Inhibits β2-Integrin(Mac-1)-mediated Neutrophils Adhesion高碘酸氧化肝素β2-整合素Mac-1嗜中性粒细胞人脐静脉内皮细胞 RO-heparinβ2-integrin Mac-1human umbilical endothelial cells HUVECsinflammationThe...
Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting th
Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin 2020, Frontiers in Cell and Developmental Biology C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation ...
Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin. Through its apo(a) moiety Lp(a) specifically interacts with the beta2-integrin Mac-1, thereby promoting the adhesion of monocytes and their ... SN Sotiriou,VV Orlova,N Alfakhri,... -...
Mac-1 (CD11b/CD18) is the pre- dominant beta 2 (CD 18) integrin mediating human neutrophil migration through synovial and dermal fibroblast barriers. Immunology. 1996;88:463-470.Gao J-X, Issekutz AC. Mac-1 (CD11b/CD18) is the predominant β2 (CD18) integrin mediating human neutrophil...
Mac-1 (CR3, CD11b/CD18) is a member of the β2 integrin family, which includes Mac-1, LFA-1 (CD11a/CD18), and gp150/95 (CR4, CD11c/CD18).18,19 These receptors, sharing a common β-chain (CD18), can bind multiple ligands and can regulate various leukocyte functions. Mac-1 ...
These results identify PF4 as a ligand for the integrin Mac-1 and suggest that many immune-modulating effects previously ascribed to PF4 are mediated through its interaction with Mac-1. 展开 关键词: platelet integrin chemokine macrophage phagocytosis alarmins Mac-1 PF4 ...
CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen. 适用物种 : Mouse 应用范围: FC 应用说明 : The amount of ...