摘要 Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a comprehensive characterization of temporal changes in cell metabolism, cellu...
In macrophage therapy, we typically use autologous cells.We take a subset of macrophages from the patient’s bloodstream andpolarizethem all into M2 macrophages. Thus, they acquire anti-inflammatory properties and promote tissue repair and wound healing. Monocytes’ polarization leads to producing 2 ...
Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int. J. Cancer 127: 899-909.Van Dongen M, Savage ND, Jordanova ES, Briaire-de Bruijn IH, Walburg KV, Ottenhoff TH, Hogendoorn PC, van der Burg SH, Gelderblom H...
Distribution and proportion of M1/M2 macrophages in periodontal tissues in rats with and without periodontitis LIANG Hongling, CHEN Bin, HE Shasha, XIE Xiaoting, YAN Fuhua Author information+ 文章历史+ 摘要 目的了解大鼠牙周炎和牙周健康状态时牙周组织中M1/M2型巨噬细胞的分布和比例。方法选取雄性SD大鼠...
巨噬细胞浸润率高与乳腺癌预后不良有关,肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)是肿瘤浸润免疫细胞中最典型的类型,从乳腺癌早期癌变到进展,尤其是转移,它们都发挥着重要作用[6]。TAMs参与乳腺癌的转移、血管生成、基质重塑、侵袭和免疫抑制。
从8周龄雌性C57BL/6小鼠的股骨骨髓中分离骨髓来源巨噬细胞(bone marrow derived macrophages,BMDM),用含10%胎牛血清、1%青霉素/链霉素的DMEM培养基和小鼠巨噬细胞集落刺激因子M-CSF(50 ng/mL)进行培养,置于37℃、5% CO2的培养箱中培...
近日,来自浙江大学医学院第二附属医院重症医学科的研究者们在J Extracell Vesicles杂志上发表了题为“Extracellular vesicles derived from M2-like macrophages alleviate acute lung injury in a miR-709-mediated manner”的文章,该研究表明,m2φ - ev在ALI/ARDS的发病机制中发挥保护作用,部分由miR-709介导,为评估...
CD206: CD206, also known as mannose receptor C type 1 (MRC1), is a membrane-bound protein primarily expressed on the surface of macrophages. CD206 is one of the most commonly used markers for identifying M2 macrophages, a subtype of macrophages that play a critical role in tissue repair ...
chenksh2002@163.com【Abstract】 ObjectiveTo induce the human mononuclear cells to type M2 macrophages and to in-vestigate the feasibility of inducting type M2 macrophages to MI macrophages.MethodsHuman mononu—clear cells were obtained through the positive magnetic bead separation method from fresh ...
Exosomes derived from induced pluripotent stem cells suppresses M2-type macrophages during pulmonary fibrosis via miR-302a-3p/TET1 axisAuthor(s): Yan Zhou , Yuan Gao , Wei Zhang , Yingying Chen , Minglan Jin , Zehui Yang Publication date Created: October 2021 ...