The molecular basis of receptor/G protein coupling selectivity was studied by using the m2 muscarinic receptor, a prototypical Gi/o-coupled receptor as a model system. We could recently show that the m2 receptor can efficiently interact with mutant G protein αq subunits in which the ...
Official Full Namecholinergic receptor muscarinic 2 Synonyms- Location7q33 Gene Typeprotein-coding gene Uniprot IDP08172 Pathway/Libraryothers Gene SummaryThe muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by...
英文名称:Recombinant Cholinergic Receptor, Muscarinic 2 (CHRM2) 分子式:电询 纯度:99 % 产地:进口/国产 品牌:钰博生物 包装规格:50ug 别名:电询 毒蕈碱型胆碱受体M2(CHRM2)重组蛋白 FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES!
G protein-coupled receptorsI KAChCardiac myocytesRecently, it has been shown that G protein-coupled receptors (GPCRs) display intrinsic voltage sensitivity. We reported that the voltage sensitivity of M2 muscarinic receptor (M2R) is also ligand specific. Here, we provide additional evidence to ...
ChRM2 ( muscarinic acetylcholine receptor M2 ) 毒蕈碱型乙酰胆碱受体通过与G蛋白偶联,调节各种细胞应答,包括抑制腺苷酸环化酶,降解磷酸肌醇和调节钾通道。 毒蕈碱型乙酰胆碱受体(又称:Cholinergic receptor,mucarinic 2)是一类可以被毒蕈碱激活而受阿托品抑制的受体.此抗体真对Cholinergic receptor,mucarinic 2蛋白的...
protein-glutamine gamma-glutamyltransferase activityprotein bindingmetal ion bindingtransferase 参与通路 phospholipase C-activating G-protein coupled receptor signaling pathwaypeptide cross-linkingnegative regulation of endoplasmic reticulum calcium ion concentrationpositive regulation of apoptotic processapoptotic cell ...
KL185Hu01 睫状神经营养因子受体(CNTFR)重组蛋白 Recombinant Ciliary Neurotrophic Factor Receptor (CNTFR) Homo sapiens (Human) kl146Hu01 含δ/Notch样EGF重复蛋白(δNER)重组蛋白 Recombinant Delta/Notch Like EGF Repeat Containing Protein (dNER) Homo sapiens (Human) ...
Real-time PCR结果显示PA显著上调巨噬细胞M1型标志物肿瘤坏死因子α和IL-6(F≥22.68,P值均< 0.01)的mRNA表达;OA上调M1型标志物IL-6(F= 22.68,P< 0.01)及M2型标志物甘露糖受体c2(mannose receptor c type 2,Mrc2)、IL-10(...
We have expressed a functional human muscarinic M2 receptor, under the control of the homologous discoidin Ipromoter, in the cellular slime mold. The use of a contact site A leader peptide ensured insertion of the newly synthesized receptor protein into the plasma membrane. Due to the ...
AKT2的激活优先发生在M1型极化过程中(图2A),这也得到了先前研究结果的支持。其他信号通路的激活主要与 M1 型极化有关,但其在 M1 型极化中的作用迄今尚未得到很好的证实,这些信号通路包括 PRKCH、RET、PRKCQ、PRKG1(和异构体 2)、TAK1、RPS6KA1、JNK1、PRKD1、MAPKAPK2 和 MERTK(图 2A)。