Macrophages have also gained attention as an immunotherapy owing to their immunomodulatory capacity and ability to infiltrate solid tumors and phagocytize tumor cells. The first-generation CD3味-based CAR-macrophages could phagocytose tumor cells in an antigen-dependent manner. Here we engineered ...
MACROPHAGESPHENOTYPESA polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections.is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a ...
Lei A, Yu H, Lu S, et al. A second-generation M1-polarized CAR macrophage with antitumor efficacy[J]. Nature Immunology, 2023: 1-15. Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological malignancies. Macrophages have also gained attention as an immunotherapy ...
摘要 Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors influence macrophage polarization, relatively little is known about how physical cues present in the extracellular environment might modulate p...
参考资料: [1] Guo, D., Lin, C., Lu, Y. et al. FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone Res 10, 45 (2022). https://doi.org/10.1038/s...
病理上,脊髓损伤(SCI)后血脊髓屏障(BSCB)破裂导致大量周围巨噬细胞浸润到损伤区域,并在新生血管周围聚集。M1极化的巨噬细胞在SCI过程中起着至关重要的作用。今天小编给大家介绍于2020年3月发表在影响因子为9.986的“Redox Biology”上的文章“Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impa...
Piaopiao Wang, Huihui Wang, QianqianHuang, Can Peng, Liang Yao, Hong Chen, Zhen Qiu, Yifan Wu, Lei Wang, Weidong Chen. Exosomes from M1Polarized Macrophages Enhance Paclitaxel Antitumor Activity by Activating MacrophagesMediat...
Science, 2021. 371(6527). 2. Gather, L., et al., Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin. J Invest Dermatol, 2022. 142(12): p. 3136-3145.e11. 发布于 2023-03-21 14:56・上海 巨噬细胞 皮肤护理 ...
To obtain M1-polarized macrophages, cells were incubated with lipopolysaccharides from Escherichia coli O111:B4 (LPS) (Sigma-Aldrich, USA) (100 ng/mL) for 24h. Polarization of macrophages was confirmed by real-time PCR and Western blot analysis. Non-polarized macrophages cultured in nutrient mediu...
Macrophages have also gained attention as an immunotherapy owing to their immunomodulatory capacity and ability to infiltrate solid tumors and phagocytize tumor cells. The first-generation CD3ζ-based CAR-macrophages could phagocytose tumor cells in an antigen-dependent manner. Here we engineered ...