Data from humans, mice and rats were subcategorized, thus in every section were highlighted the contribute, in peripheral blood and synovial tissue, of both polarized macrophages; section for endogenous molecules and drugs that favor the switch from M1 to M2 macrophages were carried out. The most...
Figure 3 Immunohistochemical staining for CD163 in M2 macrophage in the PH and CP groups Full size|PPT slide 2.3 细胞计数及统计分析 PH组M1型巨噬细胞计数为12.17 ± 1.40,CP组M1型巨噬细胞计数为40.00 ± 3.20,CP组明显高于PH组,两组差异具有统计学意义(t= 7.96,P<0.001)。PH组M2型巨噬细胞计数为...
摘要 Cyclic GMP-AMP synthase (cGAS), as a cytosolic DNA sensor, plays a crucial role in antiviral immunity, and its overactivation induces excess inflammation and tissue damage. Macrophage polarization is critically involved in inflammation; however, the role of cGAS in macrophage polarization during ...
It is well known that different macrophage types vary in their functions and, consequently, the cytokines that they secrete [59]. M1 macrophages express high levels of pro-inflammatory cytokines such as TNF-α, IL-12, and IL-23 and low levels of IL-10. In contrast, M2 macrophages secrete...
We found that tumor-conditioned medium or recombinant TGF-β was efficient to induce LD formation in Raw264.7 cells and the inhibition of LD was associated with the switch of M2 to M1 phenotype involving MEK1/2 axis. Signature molecules of M2 polarized macrophages like CD206 were also ...
Apoptotic cells released sphingosine-1-phosphate (S1P), which caused a macrophage phenotypic switch from M1 to M2. THP-1 M0 macrophages did not induce cancer cell apoptosis in our co-culture system and no phenotypic switch was observed after co-culture with etoposide. However, the kinetic used...
M1 polarization and promoted M2 polarization via STAT3 activation. Addition of HB- EGF to LPS-stimulated macrophages suppressed the pro-apoptotic effects of the macrophages on FHs-74 cells. In vivo, we found enhanced intestinal macrophage infiltration in pups subjected to NEC, the majority of which...
目前根据活化状态和发挥功能的 不同, 巨噬细胞主要可分为 M1型即经典活化的巨 噬细胞( classically activated macrophage) ,和 M2 型即替代性活化的巨噬细胞( alternatively activated macrophage) 3, 4 。在体外培养条件下,通过 IFN -C 及脂多糖( lipopolysaccharides,LPS) 诱导产生 M1 型巨噬细胞和通过 T h2...
Then, we studied how SCARB1 in EVs affected M2 macrophage function by regulating CYP1B1. Since the function of CYP1B1 has been reported to be related to phagocytosis and specifically elevated significantly in M2 macrophages, we investigated the effect of NPC-EVs on M2 macrophage phagocytosis. Th...
7). These results further confirm that macrophage p38α induces a macrophage polarity switch to the M1 phenotype and enhances pro-inflammatory factors, which contribute to the pathogenesis of nutritional steatohepatitis. Pharmacological inhibition of p38α has proven to be effective in treating or ...