Mesenchymal stromal cells (MSCs) have been widely reported to promote M1 to M2 macrophage transition; however, it is unclear whether MSCs can drive this transition in the hypoxic environment typically observed in chronic wounds. Here we report on the effect of hypoxia (1% O2) on MSCs' ability...
However, whether Cy-3-g exerts anti-inflammatory effects by modulating macrophage polarization remains unclear. Lipopolysaccharide (LPS) was used to establish the M1 model of J774 cells, in which the effects of Cy-3-g on M1-M2 conversion were explored. Cy-3-g (1, 10, 100 μM) not ...
M1 enhanced the sensitivity of A549 to cisplatin and decreased the tube formation activity and cell viability of A549 cells by inducing apoptosis and senescence. Different macrophage subtypes regulated genes involved in the immune response, cytoskeletal remodeling, coagulation, cell adhesion, and apoptosis...
M2 macrophage phenotypes, some studies suggest that CD32 may be preferentially expressed in M1 macrophages. For instance, a study by Wong et al. (2016) found that CD32 expression was upregulated on M1-like macrophages stimulated with LPS and IFN-γ, compared to M2-like macrophages stimulated ...
9.Qin, H., et al., SOCS3 deficiency promotes M1 macrophage polarization and inflammation. Journal of immunology, 2012. 189(7): p. 3439-48. 10.Gao, C.H., et al., Lactoferrin-Containing Immunocomplexes Drive the Conversion of Human Macrophages from M2- into M1-like Phenotype. Frontiers ...
SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation 热度: Macrophage polarization tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes 热度: m0 m1 m2 m3 M0 M1 M2 M3基本概念和含义详解 热度: AcceptedManuscript ...
macrophages (M1) support Th1 responses and tumoricidal action. Alternately activated macrophages (M2), on the other hand, have anti-inflammatory properties and trigger fibrosis, tumor growth, and progression. For the treatment of autoimmune disorders and cancer, macrophage reprogramming may be an ...
Our results indicated that FTO was downregulated in both M1 and M2 macrophage polarization. Silencing FTO not only inhibited M1 polarization but also restrained M2 polarization. Mechanistically, FTO knockdown led to a decrease in STAT1 and PPAR-γ transcripts, which might be the result of ...
DYNAMIC CHANGES OF MACROPHAGE M1/M2 POLARIZATION IN MONOCROTALINE ㊣NDUCED PULMONARY ARTERIAL HYPERTENSIONdoi:10.1111/resp.13206_181NoneJohn Wiley & Sons, LtdRespirology
activation as “M1 vs. M2.” “M1” activation describes a macrophage performing “classical” anti-microbial functions, while “M2” activation encompasses the “alternative;” quite literally everything else— from helminth defense, to tissue repair in the wake of an oxidative burst, to feed-...