Methods LysM + immune cells were depleted with diphtheria toxin (DTX) in LysMCre +/- iDTR +/- mice for 6 days prior to noise exposure (mean SPL; 72dBA) and 4 days concurrently. Blood pressure was determined by tail cuff method. Endothelial dysfunction was measured with isometric tension ...
g The amount of insulin in pancreatic tissues from Rip2f/f, Ins2Cre, and Rip2beta-cko mice. Nuclei were counter-stained in blue (a, c, d–f). Scale bars, 10 μm in a, c, d, f, 50 μm in e. Each symbol represents an individual animal, and horizontal bars indicate median...
we were able to evaluate the activation of microglia and identify CD11b+and CD11b−infiltrates from the periphery in the brains of LysMCre+/+iDTR+/+mice.bCD68, CD86, and MHC-II are markers of microglial activation, demonstrating that both noise and DTX activate central immune responses.cCD...
Analysis of the blood and bone marrow of thelys-EGFP mice revealed that most myelomonocytic cells, especially mature neutrophil granulocytes, were fluorescence-positive, while cells from other lineages were not. Removal of the neogene through breeding of the mice with the Cre-deleter strain led to...
To determine whether IKKβ was deleted in this preserved Ly6Cpopulation, we repeat the analysis with pups of Lys-M cre IKKβmice bred with mT/mG mice to identify the specific cell population undergoing cre-recombination, as they express GFP. We found that, in dam fed pups, LysM-cre ...
In the AOM/DSS model, endoscopic monitoring of tumor progression revealed a lowered number of adenomas within the colon of LysMCre/ ;Nod2fl/fl mice, associated with less expression of Tgfb. Mechanistically, lysozyme M was required for the improved disease severity in mic...
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