In contrast, no significant deletion was observed in tail DNA or purified T and B cells. Taken together, LysMcre mice allow for both specific and highly efficient Cre–mediated deletion of loxP–flanked target genes in myeloid cells.doi:10.1023/A:1008942828960B.E. Clausen...
Mcpip1 fl/fl LysM Cre mice as an animal model of TNFa-dependent liver endothelial cell dysfunction in humans with chronic inflammationdoi:10.1016/S0168-8278(22)01835-9Dariusz ZurawekNatalia PydynPiotr MajorEdyta KusStefan ChlopickiAndrzej Budzyński...
The mgmt null protective effect was lost in CLP mice without antibiotics, highlighting the importance of microbial control during sepsis immune modulation. However, an MGMT inhibitor in CLP with antibiotics in WT mice attenuated serum cytokines but not mortality, requiring further studies. In ...
To test the contribution of LysM in sterile acute lung injury, we generated LysMCre mice homozygous for the Cre allele (+/+) or wild-type allele (?/?). These mice were challenged with LPS delivered via oropharygneal aspiration. Mice were monitored and weighed daily, and BAL cell counts,...
LABORATORY miceANIMAL disease modelsMACROPHAGESSALMONELLA diseasesUNITS of timeHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-deriv...
Wound healing rate in FOXO3 and FOXO3 LysM-cre knockout mice compared to control.Karl, Markus RoupéSrinivas, VeerlaJoshua, OlsonErica, L. StoneOle, E. SørensenStephen, M. HedrickVictor, Nizet
Socs3fl/fl LysM cre mice show higher susceptibility to infection with M. tuberculosis.doi:10.1371/journal.ppat.1003442.g001Carow BeritReuschl Ann-KathrinGavier-Widén DoloresJ. BrendanErnst MatthiasYoshimura AkihikoJ. BenedictE. Martin
Deletion of LysM in LysMCre Recombinase Homozygous Mice is Non-contributory in LPS-Induced Acute Lung Injurydoi:10.1007/s00408-019-00286-5Ke-Qin GongCharles FrevertAnne M ManiconeLung
In mice, the mgmt null group demonstrated lower serum TNF-伪, IL-6, and IL-10 than control mice after either single or double LPS stimulation. Suppressed cytokine production resulting from an absence of mgmt in macrophages caused less severe LPS-induced inflammation but might worsen LPS ...
LysMcre;Arg1F/F mice have significantly more virus-specific CD8+ T cells in inflamed muscle tissue than WT mice at 10 dpi.Kristina, S. BurrackJeslin, J. L. TanMary, K. McCarthyZhisheng, HerJennifer, N. BergerLisa, F. P. Ng