ATXN1[82Q];IKKβF/F;LysM Cre mice showed reduced cerebellar microglial density and production of TNFα compared to ATXN1[82Q] mice, yet reducing NF-κB did not ameliorate motor impairments and cerebellar cellular pathologies. Unexpectedly, at 12 weeks of age, control IKKβF/F;LysM Cre ...
In contrast, when LysM-Cre was used (LysM-Cre CSFR1-DTR mice), pups had decreased Ly6C+ monocytes but the CD206+MHCIIand+ populations were not depleted. These results were confirmed by immunofluorescent staining for CD206 and IBA-1. Thus, we conclude that neonatal intestinal CD206+MHCII...
In contrast, no significant deletion was observed in tail DNA or purified T and B cells. Taken together, LysMcre mice allow for both specific and highly efficient Cre–mediated deletion of loxP–flanked target genes in myeloid cells.doi:10.1023/A:1008942828960B.E. Clausen...
Mcpip1 fl/fl LysM Cre mice as an animal model of TNFa-dependent liver endothelial cell dysfunction in humans with chronic inflammationdoi:10.1016/S0168-8278(22)01835-9Dariusz ZurawekNatalia PydynPiotr MajorEdyta KusStefan ChlopickiAndrzej Budzyński...
To test the contribution of LysM in sterile acute lung injury, we generated LysMCre mice homozygous for the Cre allele (+/+) or wild-type allele (?/?). These mice were challenged with LPS delivered via oropharygneal aspiration. Mice were monitored and weighed daily, and BAL cell counts,...
Additionally, p65fl/fl/LysMCre mice, especially females, display splenomegaly, but no other obvious physical or behavioral differences as compared to control animals. As bone marrow-derived macrophages from this transgenic model are almost completely devoid of canonical nuclear factor...
Stat3fl/fllysm cre mice are resistant to infection with M. tuberculosis.Gao, YuIgnacio Basile, JuanClasson, CajsaGavierWiden, DoloresYoshimura, AkihikoCarow, BeritE. Rottenberg, Martin
Socs3fl/fl LysM cre mice show higher susceptibility to infection with M. tuberculosis.doi:10.1371/journal.ppat.1003442.g001Carow BeritReuschl Ann-KathrinGavier-Widén DoloresJ. BrendanErnst MatthiasYoshimura AkihikoJ. BenedictE. Martin
Deletion of LysM in LysMCre Recombinase Homozygous Mice is Non-contributory in LPS-Induced Acute Lung Injurydoi:10.1007/s00408-019-00286-5Ke-Qin GongCharles FrevertAnne M ManiconeLung
Methods The LysMCre-Socs3 fl/fl Cx3cr1 gfp/gfp double knockout (DKO), LysMCre-Socs3 fl/fl , Cx3cr1 gfp/gfp and Socs3 fl/fl mice were maintained up to 12 months. Eyes were collected and processed for immunohistochemistry of IBA-1, cone arrestin, secretagogin, PKCα and GABA. ...