The digested food then diffuses through the vacuole membrane and enters the cell to be used for energy and growth. Autolytic Action Cell organelles that need to be ridden are covered by vesicles or vacuoles by the process of autophagy to form autophagosome. The autophagosome is then destroyed by...
1983. Effect of chloroquine on the form and function of hepatocyte lysosomes: mor- phologic modifications and physiologic alterations related to the biliary excretion of lipids and proteins. Gastroenterology. 85:1146-1153.Sewell RB, Barham SS, LaRusso NF. Effect of chloroquine on the form and ...
Upon uptake, proteins and soluble components from the extracellular space pass through endosomes before fusing and/or maturing to form lysosomes. During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Latest Research and ...
Form and function of lysosomes in oral epithelium. MUCH of the acid hydrolytic enzyme activity of many tissues is believed to reside in membrane-bound bodies termed lysosomes 1,2 . The cells of the oral epi... WATERHOUSE, J. P,SQUIER, C. A - 《Nature》 被引量: 13发表: 0年 ...
Function of lysosomes Recent discoveries have changed the former consideration of lysosomes as organelles that degrade and recycle cellular waste. It is now clear that lysosomes are key organelles in degradation, innate and adaptive immunity, and nutrient sensing [28]. Tempting researches have highlighte...
(also referred to as lytic granules). Moreover, the secretory lysosomes form part of the acidic Ca2+stores in the cells and contribute to the global Ca2+-flux and downstream effector function in NK cells. These findings connect homeostatic receptor input to lysosomal homeostasis, which tune the...
We report here the effect of chloroquine and methylamine two lysosomotropic drugs, on the binding, uptake and subcellular localization of fluorescein-label... YJ Schneider,A Trouet - 《European Journal of Biochemistry》 被引量: 81发表: 1981年 Effect of chloroquine on the form and function of hep...
the organelle. Here, we collectively classify these coordinated pathways as the lysosomal processing and adaptation system (LYPAS). We review evidence that the LYPAS is upregulated by diverse cellular stresses, its adaptability regulates senescence and cell death decisions, and it can form the basis...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Lysosomes and alpha-synuclein form a dangerous duet leading to neuronal cell death. Front. Neuroanat. 8, 83. B Mathieu,B Erwan,D Benjamin - 《Frontiers in Neuroanatomy》 被引量: 71发表: 2014年 Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein Neu...