The digested food then diffuses through the vacuole membrane and enters the cell to be used for energy and growth. Autolytic Action Cell organelles that need to be ridden are covered by vesicles or vacuoles by the process of autophagy to form autophagosome. The autophagosome is then destroyed by...
Upon uptake, proteins and soluble components from the extracellular space pass through endosomes before fusing and/or maturing to form lysosomes. During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Latest Research and ...
Lysosomes are heterogeneous in morphol- ogy, distribution, and function depending on the species and cell type. They can rapidly change their distribution, number, size, and activity to meet cellular needs. The formation of primary lysosomes requires fusion between endosomes and Golgi-derived vesicles...
We further demonstrate that the secretory function of the Golgi apparatus is critical to maintain keratinocyte lysosomes. Our study uncovers a novel form of Golgi-lysosome cross-talk and its role in maintaining specialized secretory lysosomes in differentiated keratinocytes....
Function of lysosomes Recent discoveries have changed the former consideration of lysosomes as organelles that degrade and recycle cellular waste. It is now clear that lysosomes are key organelles in degradation, innate and adaptive immunity, and nutrient sensing [28]. Tempting researches have highlighte...
Unfortunately, the detailed analysis of the function of organelle labile Fe(II) in oxidative damage and lethality of the cells has not been demonstrated so far... T Hirayama,A Miki,H Nagasawa - 《Metallomics》 被引量: 0发表: 2019年 A new lysosomal-targeted photosensitizer based on bodipy ...
Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organe... JP Luzio,BA Rous,NA Bright,... - 《Journal of Cell Science》 被引量: 426发表: 2000年 Endosome function and dysfunction in Alzheime...
Recent evidence suggests that TRPML1 and TFEB may form a positive-feedback loop in regulating autophagy9,10. In HEK293 cells stably expressing mCherry–TFEB (TFEB stable cells), we found that a mild increase in ROS levels due to CCCP treatment (5 μM for 1 h) was sufficient to ...
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(also referred to as lytic granules). Moreover, the secretory lysosomes form part of the acidic Ca2+stores in the cells and contribute to the global Ca2+-flux and downstream effector function in NK cells. These findings connect homeostatic receptor input to lysosomal homeostasis, which tune the...