96 In the years since, this locus has been conclusively linked to the target TMEM106B by multiple groups,97, 98 and TMEM106B has been shown to localize to and affect the function of lysosomes.99, 100, 101, 102 Moreover, genetic variation at the TMEM106B locus has been shown to ...
4a, b.i). This increase in intracellular ~ 70 kDa PGRN was accompanied by a small increase in GRN-2,3 peptide signal, which indicates that at least some of the protein entered lysosomes and was cleaved into individual GRN peptides (Fig. 4a, b.ii). Exposing R493X−/− KI ...
A simple AP1 knock-down experiment with a Tac-TRPML1 N-terminus construct should clarify this point. Furthermore, it has recently been reported in human fibroblasts that TRPML1 may play a role in lysosomal exocytosis [48]. This process is characterized by fusion of lysosomes with the plasma ...
The cells are also rich in lysosomes, mitochondria and lipofuscin and feature a prominent Golgi apparatus, especially when the secretion phase is active. Myoepithelial cells are also dispersed throughout the lining of the secretory segment. Their function is to aid excretion with their contractions....
Given these strong cytotoxic capabilities of Fas ligand, it is obvious that its function has to be strictly regulated to avoid uncontrolled damage. In hematopoietic cells, the death factor is stored in secretory lysosomes and is mobilised to the immunological synapse only upon activation. The ...
thatarelargerthanvesiclesStorematerialsthatoccurinexcessOthersveryspecialized(contractilevacuole)PlantscellstypicallyhaveacentralvacuoleUpto90%volumeofsomecellsFunctionsin:Storageofwater,nutrients,pigments,andwasteproductsDevelopmentofturgorpressureSomefunctionsperformedbylysosomesinothereukaryotes44VacuolesMembranoussacsthat45...
When instigated by the optogenetic tool, mitochondrial fission is reversible. After light excitation is withdrawn, the lysosomes and mitochondria can separate and mitochondrial fusion can be restored. In addition, the optogenetic method maintains the integrity of functional proteins, whereas biological metho...
[148]. In addition to HSP70, there is similar acetylation, but the site is unknown. After acetylation of PKM2, HSP70 can acetylate PKM2, which mediates intracellular localization of lysosomes, such maintaining intracellular homeostasis [142]. Table3summarizes the various post-translational modification...
Notch receptors in endosomes have two fates, they can either be recirculated to the cell membrane and cleaved to the NICD (the E3 ubiquitin ligase Deltex acts as an activator of Notch, capable of upregulating Notch), or they are translocated to lysosomes for degradation. In signaling cells, ...
These compounds affect the functional integrity of lysosomes, which appear ultrastructurally to be enlarged and filled with membranous lamellae or myelin figures. Examples of compounds known to induce these types of effect include chloroquine, triparanol and chlorphentermine. Another class of compounds ...