96 In the years since, this locus has been conclusively linked to the target TMEM106B by multiple groups,97, 98 and TMEM106B has been shown to localize to and affect the function of lysosomes.99, 100, 101, 102 Moreover, genetic variation at the TMEM106B locus has been shown to ...
Lysosomes are membrane-bounded organelles predominantly found animal cells. Explore the definition, structure, function & diagram of lysosomes only @ BYJU'S.
correlation of protein measures quantified using the two platforms, including binding affinity of the reagent (aptamer vs. antibody), glycosylation of the protein, and limit of detection of the assay14. Given the replication sample size of the Olink platform, the post-hoc powers for replicating th...
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal structures have recently revealed how the unique protein fold of these proteins enables the catalysis of transport. The proteins have 12 transmembrane spans ...
The present review will discuss how Pb affects cross-talk among different organ systems as well as among intracellular organelles, including endoplasmic reticulum (ER), lysosomes, mitochondria, and peroxisomes. Pb-induced stress mechanisms affecting immunity, neuronal apoptosis, autophagy, and health are...
What is the primary function of this cell part, a lysosome? What are the functions of the nucleolus, rough endoplasmic reticulum, smooth endoplasmic reticulum, ribosomes, vesicles, mitochondria, lysosomes, centrosomes and centrioles, cell walls, and chloroplas ...
Despite novel therapy regimens and extensive research, chemoresistance remains a challenge in leukemia treatment. Of note, recent studies revealed lysosomes as regulators of cell death and chemotherapy response, suggesting this organelle is a novel targe
The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the malaria parasite, yet its natural function remains unresolved. We identify host-derived peptid
These compounds affect the functional integrity of lysosomes, which appear ultrastructurally to be enlarged and filled with membranous lamellae or myelin figures. Examples of compounds known to induce these types of effect include chloroquine, triparanol and chlorphentermine. Another class of compounds ...
Most nutrients are ingested in a form that is either too complex for absorption or insoluble, and therefore, indigestible or incapable of being digested. Within the GI tract, much of these substances are solubilized and further degraded enzymatically to simple molecules, sufficiently small in size,...