Lysosomes were found to have specific enzymes that could break down a cell's waste, as well as bacteria and other toxic substances. Nobel In Medicine: Recycling Cell Waste As a lysosome inhibitor, CQ led to the aggregation of autophagosomes and increased LC3-II level in diosgenin-treated K562...
The cell biology of the retinal pigment epithelium Aparna Lakkaraju, ... David S. Williams, in Progress in Retinal and Eye Research, 2020 6.4.2 Location and function of lysosomes in the RPE Late endosomes mature into lysosomes, which are the major degradative compartments in the cell. Lysosome...
Although the pathogenesis of Parkinson's disease (PD) is considered multifactorial, evidence from genetics and cell biology has implicated specific molecular pathways. This article summarizes evidence that suggests that the level of intracellular alpha-synuclein is critical for the onset of neurodegeneration...
Since the discovery of lysosomes by Christian de Duve in the 1950s (de Duve, 2005), much has been learned about their biology and function. Contrary to the long prevailing concept, they are not the dead end of the endocytic pathway, but rather a central and dynamic organelle with many ...
L Phaire-Washington,SC Silverstein,E Wang - 《Journal of Cell Biology》 被引量: 308发表: 1980年 MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP. It also caused autophagy, as indicated...
Molecular biology cDNAs of SNX1, SNX2, SNX4, SNX5, SNX6, SNX8, SNX9, SNX32, and SNX33 were obtained from an on-site human cDNA library and transferred to pXF1EG plasmid and fully sequenced with EGFP-C primer. The K135A mutation of SNX8 was done using the following primer pair:...
The basic biology of coronavirus infection has captured global attention since the beginning of the COVID-19 pandemic. Like flaviviruses, coronaviruses are a family of enveloped, positive-sense RNA viruses that rely heavily on the ER during their replication cycle [[67]]. In brief, virions unde...
RUFY3-HA-tagged construct, when expressed in HeLa cells, showed a cytosolic distribution with few punctate structures (in <20% cells with weak to moderate level of expression) visible in the perinuclear region, which could be due to limiting expression of endogenous Arl8b (see inset, ...
D.M. Ward, in Encyclopedia of Cell Biology, 2016 Conventional Lysosomes All eukaryotes possess organelles that are ascribed to have lysosomal functions, the storage, and degradation of molecules. In plants and fungi such as the model organism Saccharomyces cerevisiae, lysosomes are called vacuoles. ...
Although all MPS diseases have deficiency in the degradation of GAG and exhibit common symptoms, they have specificities both on a molecular level and in the clinical manifestations [2,8]. Lysosomes are the cellular organelles primarily affected in the MPS diseases. It has been established that ...