张惠文教授建议,对尚未发病的患者,推荐使用Lyso-Gb1作为患者体内异常底物贮积的一项监测指标:通过新生儿筛查诊断的未发病患儿,建议每年进行一次Lyso-Gb1检测;通过早期筛查诊断的先证者同胞,即由于兄弟姐妹患病而被诊断为戈谢病的无症状个体,如果尚未达到治疗的指征,建议每半年进行一次Lyso-Gb1检测。对于已经接受治疗的患...
张惠文教授建议,对尚未发病的患者,推荐使用Lyso-Gb1作为患者体内异常底物贮积的一项监测指标:通过新生儿筛查诊断的未发病患儿,建议每年进行一次Lyso-Gb1检测;通过早期筛查诊断的先证者同胞,即由于兄弟姐妹患病而被诊断为戈谢病的无症状个体,如果尚未达到治...
Furthermore, lyso-Gb1 may play an important role in the onset of monoclonal gammopathy of uncertain significance, multiple myeloma, and Parkinson's disease in GD patients.Gaetano Giuffridagrid.412844.f0000 0004 1766 6239Division of HaematologyA.O.U. Policlinico Vittorio Emanuele Catania ItalyUros ...
张惠文教授建议,对尚未发病的患者,推荐使用Lyso-Gb1作为患者体内异常底物贮积的一项监测指标:通过新生儿筛查诊断的未发病患儿,建议每年进行一次Lyso-Gb1检测;通过早期筛查诊断的先证者同胞,即由于兄弟姐妹患病而被诊断为戈谢病的无症状个体,如果尚未达到治疗的指征,建议每半年进行一次Lyso-Gb1检测。对于已经接受治疗的患...
The present invention is related to the in vitro use of lyso-Gbl as a draggable target in the development of a drug, and to antagonist of lyso-Gbl for use in the treatment and/or prevention of a disease, wherein the disease is Gaucher disease or Parkinson's diseaseCOZMA, Claudia...
The present invention is related to the in vitro use of lyso-Gb1 as a draggable target in the development of a drug, and to antagonist of lyso-Gb1 for use in the treatment and/or prevention of a disease, wherein the disease is Gaucher disease or Parkinson's disease.CLAUDIA COZMA...
In conclusion, lyso-Gb1 levels contribute to the medical decision related to the initiation of treatment, mainly among mildly affected newly diagnosed patients. For patients with a severe phenotype, as for all patients, the main value of lyso-Gb1 would be to monitor response to therapy. The ...
The present invention is related to the in vitro use of lyso-Gbl as a draggable target in the development of a drug, and to antagonist of lyso-Gbl for use in the treatment and/or prevention of a disease, wherein the disease is Gaucher disease or Parkinson's diseaseCOZMA Claudia...
Glucosylsphingosine (lyso-Gb1) plays a central role in the diagnosis and proper assessment of disease severity in Gaucher patientsRolfs, Prof. ArndtGiese, Anne KatrinZielke, SusanneCozma, Claudia
The present invention is related to the in vitro use of lyso-Gb1 as a draggable target in the development of a drug, and to antagonist of lyso-Gb1 for use in the treatment and/or prevention of a disease, wherein the disease is Gaucher disease or Parkinson's diseaseCLAUDIA COZMA...