样本:Lysine-specific histone demethylase 1A ELISA Kit 检测方法:详见说明书 应用:ELISA 检测限:0.312-20 ng/ml 货号:BK-F99360 是否进口:是 ELISA试剂盒实验原理: ELISA是以免疫学反应为基础,将抗原、牽9体的特异性反应与酶对底物的高效催化作用相结合起来的一种敏感性很高的试验技术。由于抗原、抗体的反应在...
CHEN, Y. ET AL.: " Lysine-specific histone demethylase 1 (LSDl): A potential molecular targetfor tumor therapy ", CRIT REV EUKARYOT GENE EXPR, vol. 22, no. 1, 2012, pages 53 - 9Chen, Y.; Jie, W.; Yan, W.; Zhou, K.; Xiao, Y. Lysine-specific histone demethylase 1 (LSD1)...
组蛋白赖氨酸特异性的脱甲基酶(lsd1)和组蛋白脱乙酰基酶(hdac)的抑制剂 Lysine-specific histone demethylase (LSDl) and histone deacetylase (HDAC) inhibitor提供了包含连接至芳族部分的苯乙肼支架的一系列的苯乙肼类似物以及它们作为赖氨酸特异性的脱甲基酶1(LSD1)和/或一种或更多种组蛋白脱乙酰基酶(HDAC)...
During the last 10 years, mounting evidence has implicated the family of lysine-specific histone demethylases as critical regulators of normal hematopoiesis, whereas their deregulation is found in a broad spectrum of hematopoietic malignancies. Here, we review recent findings on the role of these ...
Spedaletti V, Polticelli F, Capodaglio V, Schinina ME, Stano P, Federico R and Tavladoraki P (2008) Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana. Biochemistry 47: 4936-4947Spedaletti, V., Polticelli, F., Capodaglio, V., Schinina, M.E., Stano, ...
Lysine-specific histone demethylase 1A (KDM1A also known as LSD1), a FAD-dependent H3K4me1/2 and H3K9me1/2 demethylase, was found to be upregulated in several tumors and associated with a poor prognosis due to its ability to maintain CSCs staminal features. Here, we explored the ...
It is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. Lysine-specific demethylase 5D (KDM5D) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl H3...
LSD1 the first known lysine-specific histone demethylase, is an 866 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expre
lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes.HOTAIRpromotes tumor invasion and metastasis by ... L Jing,W Jing,Z Yan,... - 《Cancer Cell International》 被引量: 6发表: 2017年 Neddylation-dependent LSD1 destabilization inhibits the ...
The lysine-specific histone demethylase 1 (LSD1) is a chromatin modifying enzyme that specifically removes methyl groups from lysine 4 of histone 3 (H3-K4) and induces transcriptional repression. However, limited knowledge exists, regarding the existence and significance of LSD1 in the brain. We ...