Lysine-specific histone demethylase I ( LSDI ) : a potential molecular target for tumor therapy[J]. Crit Rev Eukaryot Gene Expr , 2012, 22 ( I ) : 53 - 59.Chen Y,Jie W,Yan W, et al.Lysine-specific histone demethylase 1 (LSD1):A potential molecular target for tumor therapy. ...
Lysine-specific histone demethylase 1A ELISA Kit的详细说明书 检测范围:0.312-20 ng/ml 使用:本试剂仅供科研使用 保存:2-8℃ 有效期:6个月 检测方法:ELISA 产品性状:96T/48T,盒装液体 贮藏条件:2-8°C ELISA技术的优越性: (一)灵敏度高 虽然酶活性调节ELISA方法的灵敏度目前并不十分理想,但在酶活性放大EL...
Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl groups from mono- and dimethylated lysine 4 and...
LSD1 the first known lysine-specific histone demethylase, is an 866 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone ...
Lysine-specific histone demethylase 1A (KDM1A also known as LSD1), a FAD-dependent H3K4me1/2 and H3K9me1/2 demethylase, was found to be upregulated in several tumors and associated with a poor prognosis due to its ability to maintain CSCs staminal features. Here, we explored the ...
组蛋白赖氨酸特异性的脱甲基酶(lsd1)和组蛋白脱乙酰基酶(hdac)的抑制剂 Lysine-specific histone demethylase (LSDl) and histone deacetylase (HDAC) inhibitor提供了包含连接至芳族部分的苯乙肼支架的一系列的苯乙肼类似物以及它们作为赖氨酸特异性的脱甲基酶1(LSD1)和/或一种或更多种组蛋白脱乙酰基酶(HDAC)...
LSD1 is a FAD-dependent amine oxidase and can specifically demethylate H3K4me2/me1 and H3K9me2/me1. 赖氨酸特异性组蛋白去甲基化酶1(lysinespecificdemethylase1,LSD1)是一个FAD依赖性胺氧化酶,它能够特异性脱去单甲基化和二甲基化H3K4和H3K9位点上的甲基基团。5) lysine-specific histone demethylase 1 ...
The lysine-specific histone demethylase 1 (LSD1) is a chromatin modifying enzyme that specifically removes methyl groups from lysine 4 of histone 3 (H3-K4) and induces transcriptional repression. However, limited knowledge exists, regarding the existence and significance of LSD1 in the brain. We ...
Pollock et al., “Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ERalpha-Dependent and -Independent Manners,” ACS Chemical Biology, 7:1221-1231 (2012). Ravina et al., “The Relationship Between CAG Repeat Length and Clinical Progression in Huntington's Di...
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including ...