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Environmental factors such as nutritional state may act on the epigenome that consequently contributes to the metabolic adaptation of cells and the organisms. The lysine-specific demethylase-1 (LSD1) is a unique nuclear protein that utilizes flavin adeno
European Journal of Medicinal Chemistry: Chimie TherapeutiqueKumarasinghe, I.R.; Woster, P.M. Cyclic by peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. Eur. J. Med. Chem. 2018, 148, 210-220. [CrossRef] [PubMed]...
Lysine-specific demethylase 1 (LSD1) is involved in gene regulation and development; however, its precise function, molecular targets and underlying mechanisms during development are poorly understood. Here we show that LSD1 is required for neuronal prog
Bioorganic & Medicinal Chemistry LettersKakizawa, T.; Ota, Y.; Itoh, Y.; Suzuki, T. Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors. Bioorg. Med. Chem. Lett. 2018, 28, 167-169. [CrossRef] [PubMed]...
we conducted functional analysis of the histone lysine-specific demethylase (LSD1) to explore the possibility that this enzyme acts as a therapeutic target in HCC. According to immunohistochemical analysis, 232 of 303 (77%) HCC cases showed positive staining of LSD1 protein, and its expression wa...
NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect. Oncotarget 2015, 6, 2865–2878. [CrossRef] [PubMed] 17. Ueda, R.; Suzuki, T.; Mino, K.; Tsumoto, H.; Nakagawa, H.; Hasegawa, M.; Sasaki, R.; Mizukami, T.; ...
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol 2015;7:505-16.Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, et al. The histone H3 lysine-27 demethylase Jmjd3...
Lysine-specific demethylase-1 (LSD1, also known as KDM1A) is a member of the flavin-containing amine oxidase family that, in general, represses transcription by removing the methyl group from mono-methylated and di-methylated lysine 4 of histone H3 (H3K4)6. LSD1 is also involved in the ...
High-throughput screening to identify inhibitors of lysine demethylases. Epigenomics 2015, 7, 57–65. [Google Scholar] [CrossRef] [PubMed] [Green Version] Fu, X.; Zhang, P.; Yu, B. Advances toward LSD1 inhibitors for cancer therapy. Future Med. Chem. 2017, 9, 1227–1242. [Google ...