Lysine-specific demethylase 6A (KDM6A; UTX); KDM6B (JMJD3)Cell culture and mouse studies suggest inhibiting JMJD3 could help treat T cell acute lymphoblastic leukemia (T-ALL).SciBX: Science-Business eXchangedoi:10.1038/scibx.2014.1063None
Intriguingly, a pro-oncogenic role for KDM6A has been reported recently in TAL1-positive leukemias [27], suggesting that the impact of KDM6A inactivation in T-ALL is context dependent. Furthermore, KDM6B, the other known H3K27 demethylase, was found to be essential for the initiation and ...
Providing comprising attached to an aromatic moiety phenelzine, phenelzine stent series of analogues, and 1 (LSD1) and / or one thereof as lysine specific demethylase or more histone use deacetylase inhibitor (HDAC) a. 当前公开的苯乙肼类似物呈现出相对于MAO和LSD2酶的对于LSD1的效力和选择性并且...
Environmental factors such as nutritional state may act on the epigenome that consequently contributes to the metabolic adaptation of cells and the organisms. The lysine-specific demethylase-1 (LSD1) is a unique nuclear protein that utilizes flavin adeno
Lysine (K)-Specific Demethylase 6AKDM6UTXdoi:10.1007/978-3-662-46875-3_101390Kdma
Jumonji domain containing 3 (JMJD3; KDM6B); lysine-specific demethylase 6A (KDM6A; UTX)An in vitro and cell culture study identified a compound that inhibited the histone demethylases JMJD3 and UTX and that could help treat autoimmune diseases. Further details on the research, next steps and...
Lysine-specific histone demethylase 1 (LSD1) is highly expressed in CRC, and closely related to the occurrence, invasion, metastasis, and drug resistance of CRC. The histone H3K27 demethylase KDM6A forms an inhibitory complex with LSD1 and other epigenetic regulators, silencing epithelial-...
Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation Annamaria Antona, Giovanni Leo, Francesco Favero, Marco Varalda, Jacopo Venetucci, Stefania Faletti, Matilde Todaro, Eleonora Mazzucco,...
Lysine-specific demethylase 1 (LSD1 or KDM1A) overexpression correlates with poor survival and castration resistance in prostate cancer. LSD1 is a coregulator of ligand-independent androgen receptor signaling promoting c-MYC expression. We examined the antitumor efficacy of LSD1 inhibition with HCI-25...
Lysine-specific demethylase 1 (LSD1) is involved in gene regulation and development; however, its precise function, molecular targets and underlying mechanisms during development are poorly understood. Here we show that LSD1 is required for neuronal progenitor cell (NPC) maintenance during cortical dev...