Definition (NCI)A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas. Definition (NCI_NCI-GLOSS)Cancer that begins in cells of the immune system...
Critically for research, appreciation of the similarities and differences between the various sub-types only surfaced in recent decades as biological understanding about the relationship between these complex malignancies, the bone marrow, the immune system and the cellular and genetic basis of malignant...
Prevalence estimates (3, 5 and 10 year) generated from incidence and survival data are given for the main lymphoma subtypes in Table 4; and the sex-specific estimates of the main B-cell lymphoma subtypes are shown side-by-side in Figure 4. Data for lymphocyte predominant nodular Hodgkin lymp...
Once inhaled, radon decay products (RDP) can be distributed to the red bone marrow and consequently may increase the risk of leukemia (Laurier et al., 2001). Since uranium miners are also exposed to gamma (γ) radiation doses, there is growing interest in understanding the risks of leukemia...
Lymphoma may present with an atypical pattern, such as involvement of subpleural and intermuscular lymph nodes (Fig. 8.1C, red arrow, andFig. 8.1D, arrows). • Although fine-needle aspiration (FNA) is the standard diagnostic procedure in the assessment of bone marrow involvement, with an NPV...
Bone marrow (BM) was isolated from the tibia of C57BL/6 mice. BM was then put in culture for 5 days to allow differentiation in bone marrow derived macrophages (BMDM) in RPMI GLUTAMAX medium (Life Technology) supplemented with 10% FCS, 50 μg/ml of penicillin/streptomycin (Invitrogen, ...
However, investigation of bone marrow iron has rarely been performed, and diagnosis of FID has not been made. Iron supplementa- tion, when defined, has mostly been given orally. Results of IV iron addition in cancer anemia In renal anemia, the concept of FID and its treatment have been ...
R80 cells showed signs of ICD after ALK inhibition by crizotinib or ceritinib (Fig. 4). Moreover, when cells were exposed to crizotinib or ceritinib and then co-cultured with bone marrow-derived dendritic cells (BMDCs), clear evidence was found that they were engulfed by BMDCs (Fig. 5A–C...
and three analyses of population-based databases. The VTE risk is the highest upfront during the first two months after lymphoma diagnosis and decreases over time. This upfront risk may be related to tumor burden and the start of chemotherapy as contributing factors. Factors consistently reported ...
The dose of NDV-MLS was calculated based on previous human clinical trial experience with oncolytic viruses [23–25]. Lymph node and bone marrow biopsies were performed prior to viral infusion and fixed in 10% formalin, paraffin-embedded, and sectioned for review by the hemato-pathologists. ...